Structural Nerve Remodeling at 3-T MR Neurography Differs between Painful and Painless Diabetic Polyneuropathy in Type 1 or 2 Diabetes.

Aged Cross-Sectional Studies Diabetes Mellitus, Type 1 / complications Diabetes Mellitus, Type 2 / complications Diabetic Neuropathies / complications Female Humans Magnetic Resonance Imaging / methods Male Middle Aged Pain / etiology Peripheral Nerves / diagnostic imaging Prospective Studies

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
02 2020
Historique:
pubmed: 1 1 2020
medline: 19 8 2020
entrez: 1 1 2020
Statut: ppublish

Résumé

Background The pathophysiologic mechanisms underlying painful symptoms in diabetic polyneuropathy (DPN) are poorly understood. They may be associated with MRI characteristics, which have not yet been investigated. Purpose To investigate correlations between nerve structure, load and spatial distribution of nerve lesions, and pain in patients with DPN. Materials and Methods In this prospective single-center cross-sectional study, participants with type 1 or 2 diabetes volunteered between June 2015 and March 2018. Participants underwent 3-T MR neurography of the sciatic nerve with a T2-weighed fat-suppressed sequence, which was preceded by clinical and electrophysiologic tests. For group comparisons, analysis of variance or the Kruskal-Wallis test was performed depending on Gaussian or non-Gaussian distribution of data. Spearman correlation coefficients were calculated for correlation analysis. Results A total of 131 participants (mean age, 62 years ± 11 [standard deviation]; 82 men) with either type 1 (

Identifiants

DOI: 10.1148/radiol.2019191347 PMID: 31891321
pubmed: 31891321
doi: 10.1148/radiol.2019191347
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

405-414

Auteurs

Johann M E Jende (JME)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0002-1387-9304

Jan B Groener (JB)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0001-7211-1883

Zoltan Kender (Z)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Christian Rother (C)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Artur Hahn (A)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Tim Hilgenfeld (T)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0002-3458-8899

Alexander Juerchott (A)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0003-0556-908X

Fabian Preisner (F)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0003-0314-6761

Sabine Heiland (S)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0002-2796-3451

Stefan Kopf (S)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Peter Nawroth (P)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Martin Bendszus (M)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).

Felix T Kurz (FT)

From the Departments of Neuroradiology (J.M.E.J., C.R., A.H., T.H., A.J., F.P., S.H., M.B., F.T.K.) and Endocrinology, Diabetology and Clinical Chemistry (Internal Medicine 1) (J.B.G., Z.K., S.K., P.N.) and the Division of Experimental Radiology, Department of Neuroradiology (S.H.), Heidelberg University Hospital, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany; German Center of Diabetes Research, München-Neuherberg, Germany (J.B.G., S.K., P.N.); and Joint Institute for Diabetes and Cancer at Helmholtz-Zentrum Munich and Heidelberg University, Germany (P.N.).
ORCID: 0000-0001-7616-7147

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Complications du diabète › Neuropathies diabétiques › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Nerfs périphériques › Structural Nerve Remodeling at 3-T MR...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Structural Nerve Remodeling at 3-T MR...