Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring.
Cajal-Retzius neurons
apoptosis
cortical development
developmental biology
excitation/inhibition ratio
mouse
neuronal activity
neuroscience
transient
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
31 12 2019
31 12 2019
Historique:
received:
24
07
2019
accepted:
06
12
2019
entrez:
1
1
2020
pubmed:
1
1
2020
medline:
13
6
2020
Statut:
epublish
Résumé
Programmed cell death and early activity contribute to the emergence of functional cortical circuits. While most neuronal populations are scaled-down by death, some subpopulations are entirely eliminated, raising the question of the importance of such demise for cortical wiring. Here, we addressed this issue by focusing on Cajal-Retzius neurons (CRs), key players in cortical development that are eliminated in postnatal mice in part via Bax-dependent apoptosis. Using Bax-conditional mutants and CR hyperpolarization, we show that the survival of electrically active subsets of CRs triggers an increase in both dendrite complexity and spine density of upper layer pyramidal neurons, leading to an excitation/inhibition imbalance. The survival of these CRs is induced by hyperpolarization, highlighting an interplay between early activity and neuronal elimination. Taken together, our study reveals a novel activity-dependent programmed cell death process required for the removal of transient immature neurons and the proper wiring of functional cortical circuits.
Identifiants
pubmed: 31891351
doi: 10.7554/eLife.50503
pii: 50503
pmc: PMC6938399
doi:
pii:
Substances chimiques
Bax protein, mouse
0
Mutant Proteins
0
bcl-2-Associated X Protein
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-15-CE16-0003-01
Pays : International
Organisme : Fondation pour la Recherche Médicale
ID : Equipe (DEQ20130326521)
Pays : International
Organisme : Fondation pour la Recherche Médicale
ID : Equipe (DEQ20150331681)
Pays : International
Organisme : European Commission
ID : ERC-2013-CoG-616080
Pays : International
Organisme : Ministry of Higher Education, Research and Innovation
ID : Fellowship
Pays : International
Organisme : Ministry of Science, Innovation and Universities
ID : BFU2015-64432-R
Pays : International
Organisme : European Commission
ID : ERC-2014-CoG-647012
Pays : International
Organisme : Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques
ID : Postdoctoral fellowship
Pays : International
Informations de copyright
© 2019, Riva et al.
Déclaration de conflit d'intérêts
MR, IG, CH, DO, FL, FR, GL, EC, SG, MA, AP No competing interests declared
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