Differential intestinal and oral microbiota features associated with gestational diabetes and maternal inflammation.
Adult
Bacteria
/ classification
Diabetes, Gestational
/ microbiology
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Humans
Inflammation
/ microbiology
Microbiota
/ physiology
Mouth
/ microbiology
Pregnancy
Pregnancy Complications
/ microbiology
Pregnancy Trimester, Third
RNA, Ribosomal, 16S
/ analysis
Saliva
/ microbiology
16S rRNA
gestational diabetes mellitus
intestinal microbiota
oral microbiota
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 08 2020
01 08 2020
Historique:
pubmed:
1
1
2020
medline:
27
10
2020
entrez:
1
1
2020
Statut:
ppublish
Résumé
Maternal microbiota is involved in many metabolic diseases. However, its role in the pathophysiology of gestational diabetes mellitus (GDM) remains unclear. In this case-control study, we performed a 16S rRNA sequencing-based microbial survey to compare the intestinal and oral microflora at third trimester during pregnancy between 30 GDM and 31 normal controls. Sequentially, a correlation-based network analysis was further performed to explore the interactions among microbiota, maternal and infant blood sugar, and inflammatory markers. Our results show that, compared with controls, the GDM cases showed significant differences in β-diversity and increased
Identifiants
pubmed: 31891538
doi: 10.1152/ajpendo.00266.2019
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM