The Significance of Molecular Biomarkers on Clinical Survival Outcome Differs Depending on Colon Cancer Sidedness.
Methylation
colon cancer
p53
prognosis
sidedness
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
01
12
2019
revised:
10
12
2019
accepted:
12
12
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
11
1
2020
Statut:
ppublish
Résumé
This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness. A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations. High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome. Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
This retrospective study focused on the correlation between molecular markers and prognostic outcomes of colon cancer patients depending on sidedness.
MATERIALS AND METHODS
METHODS
A total of 117 stage I-III colon cancer patients who underwent colectomy were enrolled. Novel methylation markers (KIF1A, PAX5 and VGF) were selected for epigenetic evaluation and p53 and ERCC1 protein expression was examined for the investigation of genetic alterations.
RESULTS
RESULTS
High frequency of methylation was observed in 68.2% of right-sided and 39.7% of left-sided colon cancer cases (p=0.004). Abnormal p53 was identified in 52.3% of right-sided and 75.3% of left-sided cases (p=0.015). In right-sided cases, highly methylated genes demonstrated significantly favorable disease-free survival (p=0.049). Regarding left-sided cases, advanced T stage (p=0.028) and abnormal p53 (p=0.028) were revealed to be significant predictive factors of the disease-free survival outcome.
CONCLUSION
CONCLUSIONS
Molecular alterations, as significant prognostic factors, might differ depending on the sidedness of colon cancers.
Identifiants
pubmed: 31892568
pii: 40/1/201
doi: 10.21873/anticanres.13941
doi:
Substances chimiques
Biomarkers, Tumor
0
Neoplasm Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
201-211Informations de copyright
Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.