Higher Biologically Effective Dose Predicts Survival in SBRT of Pancreatic Cancer: A Multicentric Analysis (PAULA-1).

Adult Aged Aged, 80 and over Disease-Free Survival Dose-Response Relationship, Radiation Female Humans Male Middle Aged Pancreatic Neoplasms / radiotherapy Radiosurgery Survival Analysis
Pancreatic cancer chemotherapy dose effect stereotactic body radiotherapy

Journal

Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988

Informations de publication

Date de publication:
Jan 2020
Historique:
received: 21 11 2019
revised: 11 12 2019
accepted: 12 12 2019
entrez: 2 1 2020
pubmed: 2 1 2020
medline: 10 1 2020
Statut: ppublish

Résumé

The purpose of the present multicentric study was to review stereotactic body radiotherapy (SBRT) with or without chemotherapy (CHT) experience in locally advanced pancreatic cancer (LAPC). Endpoints were overall survival (OS), local control (LC), and distant metastasis-free survival (DMFS). Several parameters' impact on these outcomes was assessed. Fifty-six patients with LAPC undergoing SBRT+/-CHT were included. SBRT median BED At a median follow-up of 15.0 months, 2-year OS, LC, DMFS were: 33.8% 55.4%, and 22.9%, respectively. Patients treated with BED SBRT proved to be tolerable and effective in LAPC. Moreover, BED

Identifiants

DOI: 10.21873/anticanres.13975 PMID: 31892602
pubmed: 31892602
pii: 40/1/465
doi: 10.21873/anticanres.13975
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

465-472

Informations de copyright

Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Auteurs

Alessandra Arcelli (A)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Alessandra Guido (A)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Milly Buwenge (M)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy mbuwenge@gmail.com.

Nicola Simoni (N)

Radiotherapy Unit, Azienda Ospedaliera Universitaria, Verona, Italy.

Renzo Mazzarotto (R)

Radiotherapy Unit, Azienda Ospedaliera Universitaria, Verona, Italy.

Gabriella Macchia (G)

Radiotherapy Unit, 'Giovanni Paolo II' Foundation, Catholic University of Sacred Heart, Campobasso, Italy.

Francesco Deodato (F)

Radiotherapy Unit, 'Giovanni Paolo II' Foundation, Catholic University of Sacred Heart, Campobasso, Italy.

Savino Cilla (S)

Medical Physic Unit, 'Giovanni Paolo II' Foundation, Catholic University of Sacred Heart, Campobasso, Italy.

Pierluigi Bonomo (P)

Radiation Oncology Unit, Department of Experimental and Clinical Biomedical Sciences, Azienda Ospedaliero-Universitaria Careggi (AOUC), University of Florence, Florence, Italy.

Valerio Scotti (V)

San Rossore Private Hospital, Pisa, Italy.

Liliana Belgioia (L)

Department of Radiotherapy, Policlinico San Martino, University of Genoa, Genoa, Italy.

Giorgio Tolento (G)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Francesco Cellini (F)

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.

Elisa Grassi (E)

Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Mariacristina DI Marco (M)

Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Riccardo Casadei (R)

Department of Medical and Surgical Sciences - DIMEC, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Alessio G Morganti (AG)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Silvia Cammelli (S)

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › Relation dose-effet des rayonnements › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Techniques d'investigation › Techniques stéréotaxiques › Radiochirurgie › Higher Biologically Effective Dose Predicts...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Higher Biologically Effective Dose Predicts...