Brain and bone marrow metastases from rectal cancer.
Rectal cancer
circulating tumor cells
rare metastases
Journal
Annals of gastroenterology
ISSN: 1108-7471
Titre abrégé: Ann Gastroenterol
Pays: Greece
ID NLM: 101121847
Informations de publication
Date de publication:
Historique:
received:
25
07
2019
accepted:
06
09
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
2
1
2020
Statut:
ppublish
Résumé
Despite the development of new treatment options based on the molecular characterization of colorectal cancer, 20% of patients present de novo metastatic disease, whereas 30-40% of patients who receive curative treatment relapse during follow up. Herein, we report 2 cases with rectal cancer that developed uncommon sites of metastasis; the first patient had an isolated breast metastasis, while the second patient developed bone marrow infiltration with synchronous brain metastases. In order to evaluate the uncommon metastatic pattern of rectal cancer, we detected and enumerated circulating tumor cells (CTCs) using both immunofluorescence and real-time reverse transcriptase polymerase chain reaction in these patients' peripheral blood. The procedure revealed the presence of CTCs, positive for CEACAM5 but negative for epithelial phenotype (EpCAM-), that might explain the patients' metastatic potential and survival.
Identifiants
pubmed: 31892804
doi: 10.20524/aog.2019.0423
pii: AnnGastroenterol-33-95
pmc: PMC6928473
doi:
Types de publication
Case Reports
Langues
eng
Pagination
95-97Informations de copyright
Copyright: © Hellenic Society of Gastroenterology.
Déclaration de conflit d'intérêts
Conflict of Interest: None
Références
Cancer Chemother Pharmacol. 2018 Nov;82(5):767-775
pubmed: 30094617
Arch Pathol Lab Med. 2008 Jun;132(6):931-9
pubmed: 18517275
Sci Rep. 2016 Jul 15;6:29765
pubmed: 27416752
Breast Care (Basel). 2010 Mar;5(1):23-25
pubmed: 22619637
Cancer Med. 2017 May;6(5):918-927
pubmed: 28401701
Cancer. 2007 Aug 15;110(4):731-7
pubmed: 17582626
Nat Rev Cancer. 2009 Apr;9(4):265-73
pubmed: 19262571
Diagn Pathol. 2011 May 28;6:45
pubmed: 21619688
Ann Surg Treat Res. 2018 Jan;94(1):13-18
pubmed: 29333421