CoQ
CoQ10
Hibernating myocardium
Mitochondria
PGC1α
Journal
Nutrition & metabolism
ISSN: 1743-7075
Titre abrégé: Nutr Metab (Lond)
Pays: England
ID NLM: 101231644
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
08
2019
accepted:
18
12
2019
entrez:
2
1
2020
pubmed:
2
1
2020
medline:
2
1
2020
Statut:
epublish
Résumé
Expression of mitochondrial proteins is reduced within hibernating myocardium (HM). It is unclear whether dietary supplementation with CoQ 12 swine were instrumented with a fixed constrictor around the LAD artery to induce gradual stenosis. At three months, transthoracic ECHO was performed to confirm the presence of a wall motion abnormality in the anterior wall. Animals were then randomly assigned to receive daily dietary supplements of either CoQ Mitochondrial and nuclear membranes were isolated from the LAD region. Nuclear-bound PGC1α levels were > 200-fold higher with administration of four weeks of CoQ Four weeks of dietary CoQ
Sections du résumé
BACKGROUND
BACKGROUND
Expression of mitochondrial proteins is reduced within hibernating myocardium (HM). It is unclear whether dietary supplementation with CoQ
METHODS
METHODS
12 swine were instrumented with a fixed constrictor around the LAD artery to induce gradual stenosis. At three months, transthoracic ECHO was performed to confirm the presence of a wall motion abnormality in the anterior wall. Animals were then randomly assigned to receive daily dietary supplements of either CoQ
RESULTS
RESULTS
Mitochondrial and nuclear membranes were isolated from the LAD region. Nuclear-bound PGC1α levels were > 200-fold higher with administration of four weeks of CoQ
CONCLUSIONS
CONCLUSIONS
Four weeks of dietary CoQ
Identifiants
pubmed: 31892934
doi: 10.1186/s12986-019-0418-8
pii: 418
pmc: PMC6937679
doi:
Types de publication
Journal Article
Langues
eng
Pagination
92Informations de copyright
© The Author(s). 2019.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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