Radical scavenging and antiproliferative effect of novel phenolic derivatives isolated from Nerium indicum against human breast cancer cell line (MCF-7)-an in silico and in vitro approach.


Journal

Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 09 04 2019
accepted: 02 12 2019
pubmed: 2 1 2020
medline: 11 7 2020
entrez: 2 1 2020
Statut: ppublish

Résumé

Multiple drug resistance and increased side effects due to allopathic drugs has warned scientific community with a global alarm to identify molecules from natural sources to combat diseases with minimum or no side effects. The present investigation was aimed to identify and isolate secondary metabolites from traditionally used Nerium indicum using conventional column chromatography which led to the isolation of two compounds, C-I (fractions NB4f1) and C-II (fractions NC13b1). Further characterized, it is elucidated using spectral data and identified as N-(4-hydroxy-phenyl)-2-methoxy-2-phenyl-acetamide, molecular formula C

Identifiants

pubmed: 31893365
doi: 10.1007/s11356-019-07252-x
pii: 10.1007/s11356-019-07252-x
doi:

Substances chimiques

Antineoplastic Agents 0
Phenols 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

9038-9057

Commentaires et corrections

Type : ErratumIn

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Auteurs

Thangakumar Arunachalam (T)

Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Vellore, Tamil Nadu, India.

Syed Zameer Ahmed Khader (SZA)

Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India. zameerkhader@gmail.com.

Sidhra Syed Zameer Ahmed (S)

Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.

Manimaran Vetrivel (M)

Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.

Syed Tajudeen Syed Ameen (ST)

Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Vellore, Tamil Nadu, India.

Ibrahim Sheriff Ameer Khadharu (IS)

Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Vellore, Tamil Nadu, India.

Puniethaa Prabhu (P)

Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.

Philp Robinson Jayachandran (PR)

Department of Biotechnology, K.S.Rangasamy College of Technology, Tiruchengode, Tamil Nadu, India.

Dastageer M Sabu (DM)

Department of Chemistry, C. Abdul Hakeem College, Melvisharam, Vellore, Tamil Nadu, India.

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Classifications MeSH