A systematic evaluation of poloxamers as tablet lubricants.
Dissolution
Formulation
Lubrication
Magnesium stearate
Poloxamer
Tabletability
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Feb 2020
25 Feb 2020
Historique:
received:
19
10
2019
revised:
18
12
2019
accepted:
22
12
2019
pubmed:
2
1
2020
medline:
18
11
2020
entrez:
2
1
2020
Statut:
ppublish
Résumé
Lubricants are important for both preserving the tooling of high-speed tablet presses and attaining quality tablets. Magnesium stearate (MgSt) is most commonly used due to its superior lubrication efficiency; however, it can lead to negative effects on tabletability and dissolution. In this study, we have systematically evaluated two poloxamers, P188 and P407, for their suitability as alternative tablet lubricants. For two excipients with different mechanical properties, i.e., microcrystalline cellulose and lactose, both poloxamers exhibit acceptable lubrication efficiency without negatively impacting tabletability. Compared to 1% MgSt, the performance of 2% of both poloxamers in an experimental tablet formulation of ritonavir led to better lubrication, higher tabletability, and enhanced in vitro drug release. Thus, the use of P188 and P407 as alternative tablet lubricants deserves further evaluations.
Identifiants
pubmed: 31893543
pii: S0378-5173(19)31055-5
doi: 10.1016/j.ijpharm.2019.118994
pii:
doi:
Substances chimiques
Excipients
0
Lubricants
0
Stearic Acids
0
Tablets
0
Poloxamer
106392-12-5
stearic acid
4ELV7Z65AP
Cellulose
9004-34-6
Lactose
J2B2A4N98G
Ritonavir
O3J8G9O825
microcrystalline cellulose
OP1R32D61U
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118994Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.