Recent Advances in the Rational Drug Design Based on Multi-target Ligands.

Drug Delivery Systems Drug Design Ligands Prospective Studies
Alzheimer's disease Multitarget drugs Parkinson's disease cancer neglected tropical diseases pharmacokinetic parameters

Journal

Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157

Informations de publication

Date de publication:
06 Aug 2020
Historique:
received: 15 06 2019
revised: 02 09 2019
accepted: 07 09 2019
pubmed: 3 1 2020
medline: 25 9 2020
entrez: 3 1 2020
Statut: ppublish

Résumé

Multi-target drugs have gained considerable attention in the last decade owing to their advantages in the treatment of complex diseases and health conditions linked to drug resistance. Single-target drugs, although highly selective, may not necessarily have better efficacy or fewer side effects. Therefore, more attention is being paid to developing drugs that work on multiple targets at the same time, but developing such drugs is a huge challenge for medicinal chemists. Each target must have sufficient activity and have sufficiently characterized pharmacokinetic parameters. Multi-target drugs, which have long been known and effectively used in clinical practice, are briefly discussed in the present article. In addition, in this review, we will discuss the possible applications of multi-target ligands to guide the repositioning of prospective drugs.

Identifiants

DOI: 10.2174/0929867327666200102120652 PMID: 31894741
pubmed: 31894741
pii: CMC-EPUB-103413
doi: 10.2174/0929867327666200102120652
doi:

Substances chimiques

Ligands 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

4720-4740

Informations de copyright

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Auteurs

Ting Yang (T)

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Xin Sui (X)

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Bing Yu (B)

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Youqing Shen (Y)

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

Hailin Cong (H)

Institute of Biomedical Materials and Engineering, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, China.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Recent Advances in the Rational Drug Design...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Recent Advances in the Rational Drug Design...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Recent Advances in the Rational Drug Design...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Recent Advances in the Rational Drug Design...