Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals.
Aged
Atrophy
/ pathology
Cerebral Cortex
/ diagnostic imaging
Cerebral Small Vessel Diseases
/ diagnostic imaging
Cross-Sectional Studies
Female
Forced Expiratory Volume
/ physiology
Humans
Magnetic Resonance Imaging
Male
Mental Status and Dementia Tests
Middle Aged
Vital Capacity
/ physiology
White Matter
/ diagnostic imaging
Brain atrophy
Cerebral small vessel disease
Pulmonary function
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
04
2019
revised:
13
12
2019
accepted:
21
12
2019
pubmed:
4
1
2020
medline:
18
12
2020
entrez:
4
1
2020
Statut:
ppublish
Résumé
Pulmonary dysfunction is associated with elevated risk of cognitive decline. However, the mechanism underlying this relationship has not been fully investigated. In this study, we investigate the relationships between pulmonary function, cerebral small vessel disease (CSVD) markers, cortical thickness, and the Mini-Mental Status Examination (MMSE) scores in cognitively normal individuals. We used a cross-sectional study design. We identified 1924 patients who underwent pulmonary function testing, three-dimensional brain magnetic resonance imaging (MRI), and the MMSE. Pulmonary function was analyzed according to the quintiles of percentage predicted values (% pred) for forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV Compared with the highest quintile of FVC, the lowest quintile of FVC (% pred) showed a higher risk of WMH (OR 1.98, 95% CI: 1.21-3.24) and lacunes (OR 1.86, 95% CI: 1.12-3.08). There were no associations between FVC or FEV Our findings suggested that decreased pulmonary function was associated with increased CSVD burdens, which in turn wass associated with decreased cognition, even in cognitively normal subjects.
Sections du résumé
BACKGROUND
Pulmonary dysfunction is associated with elevated risk of cognitive decline. However, the mechanism underlying this relationship has not been fully investigated. In this study, we investigate the relationships between pulmonary function, cerebral small vessel disease (CSVD) markers, cortical thickness, and the Mini-Mental Status Examination (MMSE) scores in cognitively normal individuals.
METHODS
We used a cross-sectional study design. We identified 1924 patients who underwent pulmonary function testing, three-dimensional brain magnetic resonance imaging (MRI), and the MMSE. Pulmonary function was analyzed according to the quintiles of percentage predicted values (% pred) for forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV
RESULTS
Compared with the highest quintile of FVC, the lowest quintile of FVC (% pred) showed a higher risk of WMH (OR 1.98, 95% CI: 1.21-3.24) and lacunes (OR 1.86, 95% CI: 1.12-3.08). There were no associations between FVC or FEV
CONCLUSIONS
Our findings suggested that decreased pulmonary function was associated with increased CSVD burdens, which in turn wass associated with decreased cognition, even in cognitively normal subjects.
Identifiants
pubmed: 31896465
pii: S2213-1582(19)30486-3
doi: 10.1016/j.nicl.2019.102140
pmc: PMC6940695
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102140Subventions
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing interests.