Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques.

AIDS Vaccines / genetics Animals CD40 Ligand / genetics Gene Expression Genetic Vectors / genetics HEK293 Cells HIV Envelope Protein gp120 / genetics Humans Immunogenicity, Vaccine Macaca mulatta Simian Immunodeficiency Virus / genetics Viral Vaccines / genetics

CD4 CD40L HIV MDSC NHP SIV macaques vaccine

Journal

Journal of virology

ISSN: 1098-5514

Titre abrégé: J Virol

Pays: United States

ID NLM: 0113724

Informations de publication

Date de publication:
28 02 2020

Historique:

received: 15 11 2019

accepted: 05 12 2019

pubmed: 4 1 2020

medline: 4 9 2020

entrez: 4 1 2020

Statut: epublish

Résumé

Immunization with recombinant ALVAC/gp120 alum vaccine provided modest protection from human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) acquisition in humans and macaques. Vaccine-mediated protection was associated with the elicitation of IgG against the envelope V2 loop and of envelope-specific CD4

Identifiants

DOI: 10.1128/JVI.01933-19 PMID: 31896599 PMC: PMC7158742

pubmed: 31896599

pii: JVI.01933-19

doi: 10.1128/JVI.01933-19

pmc: PMC7158742

pii:

doi:

Substances chimiques

AIDS Vaccines 0

ALVAC vaccine 0

HIV Envelope Protein gp120 0

Viral Vaccines 0

gp120 protein, Human immunodeficiency virus 1 0

CD40 Ligand 147205-72-9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : CIHR

ID : THA-11906

Pays : Canada

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