Clinicopathological features of in situ follicular neoplasm and relations with follicular lymphoma in Japan.
BCL-2
Immunohistochemistry
In situ follicular neoplasm
Pathology
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
15
07
2019
accepted:
05
11
2019
pubmed:
4
1
2020
medline:
30
1
2020
entrez:
4
1
2020
Statut:
ppublish
Résumé
This study aims to investigate the clinicopathological features of in situ follicular neoplasm (ISFN) in Japan. ISFN is a rare condition formerly considered as an early precursor of follicular lymphoma (FL). This is a first original report of ISFN from Asian country. We reviewed 19 biopsy samples of ISFN. ISFNs were categorized into two groups: (1) ISFN, consisting of ISFN with strong positivity for BCL-2 immunohistochemical staining (IHC), and obvious translocation of BCL-2; and (2) ISFN-like FL, featuring cases without obvious translocation but having morphological features and characteristic IHC findings of ISFN. As control, we adopted obvious FL. For some cases showing coexisting ISFN and FL lesions in the same lymph node, we could conduct further clonality analysis for each lesion. Nine of the 19 cases of ISFN coexisted with FL or had a history of overt B- or T-cell lymphoma including FL. Statistical comparison among ISFN-like FL and FL showed no significant differences in pathological features. Molecular analysis suggested that ISFN lesion and FL lesion in the same lymph node each have a different clonality. ISFN coexists or associates with other overt lymphomas frequently.
Identifiants
pubmed: 31897674
doi: 10.1007/s00277-019-03841-5
pii: 10.1007/s00277-019-03841-5
doi:
Substances chimiques
BCL2 protein, human
0
Proto-Oncogene Proteins c-bcl-2
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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