A comparison of three strategies for withdrawal of noninvasive ventilation in chronic obstructive pulmonary disease with acute respiratory failure: Randomized trial.
Chronic obstructive pulmonary disease
exacerbation
noninvasive ventilation
weaning
Journal
Lung India : official organ of Indian Chest Society
ISSN: 0970-2113
Titre abrégé: Lung India
Pays: India
ID NLM: 8405380
Informations de publication
Date de publication:
Historique:
entrez:
4
1
2020
pubmed:
4
1
2020
medline:
4
1
2020
Statut:
ppublish
Résumé
The optimal strategy for the withdrawal of noninvasive ventilation (NIV) remains unknown. This study was planned to compare three different strategies for the withdrawal of NIV among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF). Patients with AECOPD with HcRF who improved on NIV were randomized into three groups - immediate withdrawal (Group A), stepwise reduction of pressure support (Group B), and stepwise reduction of duration (Group C) of NIV. The probability of successful withdrawal was compared among the groups. This study included 90 patients (males - 86.6%) with a mean (±standard deviation [SD]) age of 59.9 ± 8.3 years. The mean (±SD) pH and PaCO Immediate withdrawal of the NIV after recovery of respiratory failure among patients with exacerbation of COPD is feasible. Immediate withdrawal did not increase the risk of weaning failure from the NIV.
Sections du résumé
BACKGROUND
BACKGROUND
The optimal strategy for the withdrawal of noninvasive ventilation (NIV) remains unknown. This study was planned to compare three different strategies for the withdrawal of NIV among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with hypercapnic respiratory failure (HcRF).
MATERIALS AND METHODS
METHODS
Patients with AECOPD with HcRF who improved on NIV were randomized into three groups - immediate withdrawal (Group A), stepwise reduction of pressure support (Group B), and stepwise reduction of duration (Group C) of NIV. The probability of successful withdrawal was compared among the groups.
RESULTS
RESULTS
This study included 90 patients (males - 86.6%) with a mean (±standard deviation [SD]) age of 59.9 ± 8.3 years. The mean (±SD) pH and PaCO
CONCLUSIONS
CONCLUSIONS
Immediate withdrawal of the NIV after recovery of respiratory failure among patients with exacerbation of COPD is feasible. Immediate withdrawal did not increase the risk of weaning failure from the NIV.
Identifiants
pubmed: 31898613
pii: LungIndia_2020_37_1_3_274424
doi: 10.4103/lungindia.lungindia_335_19
pmc: PMC6961096
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3-7Déclaration de conflit d'intérêts
None
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