Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin.

ADP Ribose Transferases / antagonists & inhibitors Bordetella pertussis / drug effects Drug Discovery Escherichia coli / genetics HEK293 Cells Humans Inhibitory Concentration 50 Molecular Docking Simulation Molecular Dynamics Simulation NAD / metabolism Pertussis Toxin / antagonists & inhibitors
ADP-ribosylation ADP-ribosyltransferase drug development inhibitor pertussis toxin whooping cough

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
10 04 2020
Historique:
pubmed: 4 1 2020
medline: 26 1 2021
entrez: 4 1 2020
Statut: ppublish

Résumé

The targeted pathogen-selective approach to drug development holds promise to minimize collateral damage to the beneficial microbiome. The AB

Identifiants

DOI: 10.1021/acsinfecdis.9b00412 PMID: 31899865
pubmed: 31899865
doi: 10.1021/acsinfecdis.9b00412
doi:

Substances chimiques

NAD 0U46U6E8UK
ADP Ribose Transferases EC 2.4.2.-
Pertussis Toxin EC 2.4.2.31

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

588-602

Auteurs

Yashwanth Ashok (Y)

Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Aapistie 7A, P.O. Box 5400, FI-90014, Oulu, Finland.

Moona Miettinen (M)

Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland.
Turku Doctoral Programme of Molecular Medicine (TuDMM), University of Turku, Turku, Finland.

Danilo Kimio Hirabae de Oliveira (DKH)

Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Aapistie 7A, P.O. Box 5400, FI-90014, Oulu, Finland.

Mahlet Z Tamirat (MZ)

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, FI-20520 Turku, Finland.

Katja Näreoja (K)

Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland.

Avlokita Tiwari (A)

Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland.

Michael O Hottiger (MO)

Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
ORCID: 0000-0002-7323-2270

Mark S Johnson (MS)

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, FI-20520 Turku, Finland.

Lari Lehtiö (L)

Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, Aapistie 7A, P.O. Box 5400, FI-90014, Oulu, Finland.
ORCID: 0000-0001-7250-832X

Arto T Pulliainen (AT)

Institute of Biomedicine, Research Center for Cancer, Infections, and Immunity, University of Turku, Kiinamyllynkatu 10, FI-20520 Turku, Finland.
ORCID: 0000-0002-9361-8963

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › Bordetella pertussis › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Discovery of Compounds Inhibiting the...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › Facteurs de virulence des Bordetella › Toxine pertussique › Discovery of Compounds Inhibiting the...