Repurposing a psychoactive drug for children with cancer: p27
Journal
Oncogenesis
ISSN: 2157-9024
Titre abrégé: Oncogenesis
Pays: United States
ID NLM: 101580004
Informations de publication
Date de publication:
02 Jan 2020
02 Jan 2020
Historique:
received:
04
07
2019
accepted:
03
12
2019
revised:
02
12
2019
entrez:
5
1
2020
pubmed:
5
1
2020
medline:
5
1
2020
Statut:
epublish
Résumé
The MYC family of transcription factors is a major driver of human cancer and potential therapeutic target. However, no clinically viable drugs have been yet developed that are able to directly tackle MYC oncoproteins. In our laboratory, we are exploring alternative approaches aiming to disturb signalling downstream of MYC. MYCN is frequently activated in neuroblastoma, a paediatric solid malignancy that, in its metastatic form, has a very poor prognosis. An important pathway regulated by MYC is the CKS1/SKP2/p27
Identifiants
pubmed: 31900399
doi: 10.1038/s41389-019-0186-3
pii: 10.1038/s41389-019-0186-3
pmc: PMC6949307
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : IG 15196
Organisme : Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research)
ID : IG:18467
Références
Cancer Discov. 2018 Mar;8(3):320-335
pubmed: 29284669
Bioinformatics. 2014 Apr 15;30(8):1180-1182
pubmed: 24389662
Clin Cancer Res. 2007 Aug 15;13(16):4695-703
pubmed: 17652624
Genes Dev. 2002 Oct 15;16(20):2699-712
pubmed: 12381668
Cell Death Dis. 2011 Oct 20;2:e219
pubmed: 22012253
EMBO J. 2007 May 16;26(10):2562-74
pubmed: 17464290
Mol Cell. 2005 Oct 7;20(1):9-19
pubmed: 16209941
J Autism Dev Disord. 1998 Aug;28(4):303-7
pubmed: 9711486
Lancet. 2007 Jun 23;369(9579):2106-20
pubmed: 17586306
Biochem Pharmacol. 2008 May 15;75(10):1924-34
pubmed: 18371935
Mol Pharmacol. 2018 Oct;94(4):1220-1231
pubmed: 30115672
Mol Cell. 2001 Mar;7(3):639-50
pubmed: 11463388
J Biol Chem. 2015 Jan 23;290(4):2198-212
pubmed: 25477524
Target Oncol. 2016 Apr;11(2):247-53
pubmed: 26891967
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
Cancer Lett. 2015 Jul 10;363(1):37-45
pubmed: 25843293
Int J Cancer. 2015 Mar 1;136(5):E252-61
pubmed: 25220031
Dev Cell. 2012 Aug 14;23(2):356-70
pubmed: 22898779
Cancer Res. 2018 Dec 1;78(23):6666-6679
pubmed: 30301840
Nat Cell Biol. 2001 Mar;3(3):321-4
pubmed: 11231585
Nat Rev Cancer. 2003 Mar;3(3):203-16
pubmed: 12612655
Apoptosis. 2017 Sep;22(9):1079-1097
pubmed: 28647884
J Mol Biol. 2006 Oct 27;363(3):673-86
pubmed: 16979657
Sci Rep. 2017 Aug 31;7(1):10274
pubmed: 28860499
Genes (Basel). 2017 Jun 30;8(7):
pubmed: 28665315
Nat Rev Drug Discov. 2014 Dec;13(12):889-903
pubmed: 25394868
Neuropsychopharmacology. 2005 Mar;30(3):582-9
pubmed: 15602505