Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women.
aging
atherosclerosis
carotid artery
hormones
women
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
19
07
2019
accepted:
01
01
2020
pubmed:
5
1
2020
medline:
5
1
2021
entrez:
5
1
2020
Statut:
ppublish
Résumé
Endogenous sex hormones may be involved in the pathogenesis of cardiovascular disease (CVD) in women. Carotid plaque characteristics, such as echogenicity, an ultrasound measure that reflects plaque composition, may identify unstable plaques that are more likely to rupture, precipitating a CVD event. However, few studies have considered sex steroids in relation to carotid plaque and its characteristics. To evaluate estrone (E1), estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and free T (FT) in relation to carotid plaque in women. In MsHeart, a cross-sectional study of 304 women aged 40 to 60 years, participants underwent a carotid artery ultrasound assessment. The current analysis included MsHeart participants with carotid plaque (n = 141, 46%). E1, E2, and T were assayed using liquid chromatography-tandem mass spectrometry; FT was estimated using ensemble allostery models. Regression models were adjusted for sociodemographic characteristics and CVD risk factors. Carotid plaque burden (number of plaques, total plaque area [TPA]) and characteristics (calcification, echogenicity) were determined using semi-automated software. SHBG was inversely related to TPA (odds ratio [OR] 0.39; 95% confidence interval [CI] 0.21, 0.74; multivariable) and higher FTs were associated with greater TPA (OR 2.89; 95% CI 1.31, 6.37; multivariable). Higher E1 was related to echogenicity (OR 2.31; 95% CI 1.26, 4.33; multivariable), characteristic of more stable plaque. SHBG and FT are related to TPA while E1 is related to plaque echogenicity, suggesting these hormones have different roles in the development of carotid plaque. Our findings highlight the importance of sex hormones in the development of carotid plaque in midlife women.
Identifiants
pubmed: 31900485
pii: 5695920
doi: 10.1210/clinem/dgz327
pmc: PMC7077951
pii:
doi:
Substances chimiques
Biomarkers
0
Gonadal Steroid Hormones
0
Sex Hormone-Binding Globulin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000005
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105647
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG031679
Pays : United States
Organisme : NIA NIH HHS
ID : R44 AG045011
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023461
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL083825
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL123565
Pays : United States
Organisme : NIA NIH HHS
ID : R43 AG045011
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG031206
Pays : United States
Informations de copyright
© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Circ Res. 2018 Jan 5;122(1):97-105
pubmed: 29097437
Cerebrovasc Dis. 2012;34(4):290-6
pubmed: 23128470
JACC Cardiovasc Imaging. 2014 Oct;7(10):1025-38
pubmed: 25051948
Circulation. 2005 Mar 15;111(10):1242-9
pubmed: 15769764
Clin Chem. 2004 Feb;50(2):373-84
pubmed: 14656902
J Cardiovasc Ultrasound. 2016 Jun;24(2):91-5
pubmed: 27358696
Atherosclerosis. 2009 May;204(1):255-61
pubmed: 18849030
Stroke. 2002 Dec;33(12):2916-22
pubmed: 12468791
Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):226-30
pubmed: 24177328
Endocr Rev. 2017 Apr 1;38(2):123-144
pubmed: 28323944
Cerebrovasc Dis. 2009;27(4):392-7
pubmed: 19276622
Menopause. 2017 Jul;24(7):728-753
pubmed: 28650869
N Am J Med Sci. 2013 Jun;5(6):371-6
pubmed: 23923112
J Clin Endocrinol Metab. 2008 Jan;93(1):131-8
pubmed: 17925335
Eur Heart J Cardiovasc Imaging. 2016 Sep;17(9):991-1000
pubmed: 26358694
Am J Public Health. 2008 Nov;98(11):1963-70
pubmed: 18511718
Womens Midlife Health. 2017;3:
pubmed: 29333273
Obesity (Silver Spring). 2013 Mar;21(3):629-36
pubmed: 23592672
Echocardiography. 2016 Feb;33(2):281-9
pubmed: 26122814
J Clin Endocrinol Metab. 2012 Apr;97(4):1159-68
pubmed: 22344196
J Clin Endocrinol Metab. 2002 Aug;87(8):3760-7
pubmed: 12161507
J Clin Endocrinol Metab. 2018 Aug 1;103(8):3070-3077
pubmed: 29788255
Steroids. 2008 Dec 12;73(13):1333-8
pubmed: 18565562
Hypertension. 1992 May;19(5):456-63
pubmed: 1568764
J Clin Endocrinol Metab. 2010 Feb;95(2):740-7
pubmed: 19934360
J Neuroradiol. 2017 Jul;44(4):234-240
pubmed: 28187866
Med Sci Sports Exerc. 2003 Aug;35(8):1381-95
pubmed: 12900694
Obesity (Silver Spring). 2010 Mar;18(3):604-10
pubmed: 19696765
Eur J Neurol. 2016 Jul;23(7):1241-7
pubmed: 27106563
Exp Ther Med. 2017 Apr;13(4):1337-1342
pubmed: 28413474
Stroke. 2013 Jul;44(7):1859-65
pubmed: 23735956
J Vasc Surg. 2005 Sep;42(3):435-41
pubmed: 16171584
Menopause. 2017 Aug;24(8):886-893
pubmed: 28399007
Diabetes Care. 2011 Aug;34(8):1771-7
pubmed: 21715525
J Clin Endocrinol Metab. 2010 Sep;95(9):4424-31
pubmed: 20554712
JACC Cardiovasc Imaging. 2012 Jul;5(7):681-9
pubmed: 22789936
Atherosclerosis. 2016 Apr;247:193-200
pubmed: 26926599
Mol Cell Endocrinol. 2015 Jan 5;399:190-200
pubmed: 25240469
Atherosclerosis. 2019 Oct;289:27-35
pubmed: 31446211
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):471-7
pubmed: 25550203
Endocr Rev. 2013 Jun;34(3):309-38
pubmed: 23460719
Menopause. 2011 Apr;18(4):376-84
pubmed: 21107300
Atherosclerosis. 2012 Jan;220(1):128-33
pubmed: 21764060
Atherosclerosis. 2008 Mar;197(1):132-8
pubmed: 17412347
J Am Heart Assoc. 2013 Apr 18;2(2):e000180
pubmed: 23598274
J Endocrinol Invest. 2008 Jul;31(7):597-601
pubmed: 18787375
Indian J Endocrinol Metab. 2019 Jan-Feb;23(1):60-66
pubmed: 31016155
J Clin Endocrinol Metab. 2017 Dec 1;102(12):4588-4595
pubmed: 29029113
J Clin Endocrinol Metab. 2011 Apr;96(4):1053-9
pubmed: 21239514
Eur J Vasc Endovasc Surg. 2014 Aug;48(2):118-25
pubmed: 24947079
Circulation. 2018 Mar 20;137(12):e67-e492
pubmed: 29386200
Lipids. 2009 May;44(5):397-403
pubmed: 19234732
J Clin Endocrinol Metab. 2005 Jan;90(1):157-62
pubmed: 15509641
Eur J Vasc Endovasc Surg. 1996 May;11(4):414-6
pubmed: 8846173
Arch Intern Med. 1993 Feb 22;153(4):501-6
pubmed: 8435030
ScientificWorldJournal. 2012;2012:363595
pubmed: 22701354
Maturitas. 2017 Oct;104:44-53
pubmed: 28923176
Curr Vasc Pharmacol. 2015;13(2):173-81
pubmed: 24188488
Metabolism. 2012 Feb;61(2):193-201
pubmed: 21820132
Can J Physiol Pharmacol. 2008 Jan-Feb;86(1-2):25-35
pubmed: 18418444
Endocr J. 2015;62(9):777-86
pubmed: 26073868
Climacteric. 2004 Dec;7(4):375-89
pubmed: 15799609
Pharmacol Rev. 2008 Jun;60(2):210-41
pubmed: 18579753
Thromb Res. 2018 Apr;164:9-14
pubmed: 29459247
Stroke. 2004 Feb;35(2):477-81
pubmed: 14739419
J Clin Endocrinol Metab. 2007 Feb;92(2):405-13
pubmed: 17090633
Eur J Prev Cardiol. 2016 May;23(7):694-703
pubmed: 26385249
J Clin Endocrinol Metab. 2013 Apr;98(4):1376-87
pubmed: 23463657
Eur J Vasc Endovasc Surg. 1997 Dec;14(6):439-45
pubmed: 9467517
Stroke. 2001 May;32(5):1104-11
pubmed: 11340217
Nutr Metab Cardiovasc Dis. 2010 Jul;20(6):386-93
pubmed: 20554179
J Clin Invest. 1989 Jun;83(6):1941-5
pubmed: 2723066
J Clin Endocrinol Metab. 2011 Aug;96(8):2430-9
pubmed: 21697255
Circulation. 2004 Mar 9;109(9):1089-94
pubmed: 14993130
Curr Cardiol Rep. 2009 Jan;11(1):21-7
pubmed: 19091171
Climacteric. 2008;11(6):509-17
pubmed: 18991078
Circulation. 2017 Feb 7;135(6):556-565
pubmed: 28153992