Adreno-melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma.
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
06
06
2019
revised:
05
12
2019
accepted:
09
12
2019
pubmed:
5
1
2020
medline:
22
6
2021
entrez:
5
1
2020
Statut:
ppublish
Résumé
Often, glaucoma presents with elevated eye hydrostatic pressure, which is regulated by endogenous melatonin. Phenylephrine increases cytoplasmic [Ca Biophysical and proximity ligation assays were performed to identify interactions in heterologous expression systems, in cell lines and in human eyes. G α The findings are instrumental to understand the physiological function of melatonin in the eye and its potential to address eye pathologies by targeting melatonin receptors and their complexes.
Sections du résumé
BACKGROUND AND PURPOSE
Often, glaucoma presents with elevated eye hydrostatic pressure, which is regulated by endogenous melatonin. Phenylephrine increases cytoplasmic [Ca
EXPERIMENTAL APPROACH
Biophysical and proximity ligation assays were performed to identify interactions in heterologous expression systems, in cell lines and in human eyes. G
KEY RESULTS
α
CONCLUSIONS AND IMPLICATIONS
The findings are instrumental to understand the physiological function of melatonin in the eye and its potential to address eye pathologies by targeting melatonin receptors and their complexes.
Identifiants
pubmed: 31901203
doi: 10.1111/bph.14971
pmc: PMC7161553
doi:
Substances chimiques
Antihypertensive Agents
0
Receptors, Melatonin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2090-2105Subventions
Organisme : Spanish Ministerio de Sanidad
ID : RD12/0034/0003
Pays : International
Organisme : Spanish Ministerio de Sanidad
ID : RD16/0008/0017
Pays : International
Organisme : Spanish Ministerio de Economía y Competitividad (MINECO)
ID : SAF2013-44416-R
Pays : International
Organisme : Spanish Ministerio de Economía y Competitividad (MINECO)
ID : SAF2016-77084-R
Pays : International
Organisme : Spanish Ministerio de Economía y Competitividad (MINECO)
ID : BFU2015-64405-R
Pays : International
Informations de copyright
© 2020 The British Pharmacological Society.
Références
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16086-91
pubmed: 21914848
Lancet. 2011 Apr 16;377(9774):1367-77
pubmed: 21453963
Clin Exp Ophthalmol. 2012 May-Jun;40(4):341-9
pubmed: 22356435
Adv Organ Biol. 2005 Jan 1;10:127-148
pubmed: 21234280
BMC Ophthalmol. 2018 Sep 3;18(1):233
pubmed: 30176825
Br J Pharmacol. 2018 Feb;175(3):407-411
pubmed: 29350411
J Ocul Pharmacol. 1988 Fall;4(3):203-14
pubmed: 2904473
Drugs Today (Barc). 2010 Jun;46(6):409-16
pubmed: 20571609
Nat Chem Biol. 2009 Mar;5(3):131-4
pubmed: 19219011
Comp Biochem Physiol C. 1993 Sep;106(1):189-93
pubmed: 7903612
Acta Ophthalmol Scand. 2001 Feb;79(1):6-9
pubmed: 11167277
Sci Signal. 2013 Oct 08;6(296):ra89
pubmed: 24106342
J Pineal Res. 2010 Aug;49(1):1-13
pubmed: 20492443
Br J Pharmacol. 2003 Mar;138(5):831-6
pubmed: 12642384
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):654-9
pubmed: 17194762
Exp Eye Res. 2015 Jul;136:34-7
pubmed: 25933715
Oncotarget. 2018 Feb 6;9(17):13593-13611
pubmed: 29568380
Drugs. 1977 Sep;14(3):163-97
pubmed: 143363
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21377-82
pubmed: 19948956
Auton Neurosci. 2009 May 11;147(1-2):14-9
pubmed: 19176290
Brain Behav Immun. 2018 Jan;67:139-151
pubmed: 28843453
Am J Health Syst Pharm. 2005 Apr 1;62(7):691-9
pubmed: 15790795
J Biol Chem. 2010 Aug 27;285(35):27346-59
pubmed: 20562103
FEBS Lett. 2004 Dec 3;578(1-2):116-20
pubmed: 15581627
Curr Med Chem. 2010;17(19):2070-95
pubmed: 20423309
Cell Signal. 2018 Apr;44:43-50
pubmed: 29329779
Acta Ophthalmol. 2018 May;96(3):e277-e284
pubmed: 29144028
Br J Pharmacol. 2018 Apr;175(7):987-993
pubmed: 29520785
Eurasian J Med. 2016 Jun;48(2):135-41
pubmed: 27551178
Nature. 2011 Sep 28;477(7366):611-5
pubmed: 21956331
Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
Graefes Arch Clin Exp Ophthalmol. 2008 Oct;246(10):1485-90
pubmed: 18575878
EMBO J. 2006 Jul 12;25(13):3012-23
pubmed: 16778767
J Pineal Res. 1996 Sep;21(2):101-7
pubmed: 8912235
Clin Drug Investig. 2014 Jul;34(7):521-8
pubmed: 24895141
Ann Ophthalmol. 1983 Feb;15(2):141-9
pubmed: 6301342
Nature. 2011 Jul 19;477(7366):549-55
pubmed: 21772288
Curr Eye Res. 1992 Feb;11(2):161-73
pubmed: 1572206
Br J Ophthalmol. 2015 Jun;99(6):738-45
pubmed: 25488946
Tohoku J Exp Med. 2001 Dec;195(4):219-25
pubmed: 11908823
J Ocul Pharmacol Ther. 2000 Feb;16(1):65-74
pubmed: 10673133
J Pineal Res. 2010 Oct;49(3):301-11
pubmed: 20695976
Indian J Ophthalmol. 2018 Apr;66(4):495-505
pubmed: 29582808
Exp Eye Res. 1985 Apr;40(4):591-9
pubmed: 2861105
Curr Neuropharmacol. 2010 Sep;8(3):168-81
pubmed: 21358968
Nature. 2013 Jul 18;499(7458):295-300
pubmed: 23868258
Prog Mol Biol Transl Sci. 2015;134:301-14
pubmed: 26310162
Br J Pharmacol. 2010 Aug;160(7):1577-9
pubmed: 20649561
Front Genet. 2017 Oct 12;8:144
pubmed: 29075285
Front Pharmacol. 2017 Oct 23;8:744
pubmed: 29109685
J Biol Chem. 2010 Nov 5;285(45):35092-103
pubmed: 20807772
Br J Ophthalmol. 2006 Mar;90(3):262-7
pubmed: 16488940
Regul Pept. 2013 Jun 10;184:96-103
pubmed: 23541890
Curr Med Chem. 2012;19(21):3508-22
pubmed: 22709004
Acta Ophthalmol. 2017 May;95(3):e185-e189
pubmed: 27595784
J Pharmacol Exp Ther. 2015 Jan;352(1):119-28
pubmed: 25344385
Exp Eye Res. 2014 May;122:40-9
pubmed: 24631335
Am J Med. 1989 Aug 16;87(2A):45S-52S
pubmed: 2669473
Front Pharmacol. 2016 Mar 31;7:76
pubmed: 27065866
Invest Ophthalmol Vis Sci. 1992 Oct;33(11):3186-94
pubmed: 1356946
Br J Clin Pharmacol. 1986;21 Suppl 1:69S-75S
pubmed: 2939870
Br J Pharmacol. 2019 Dec;176 Suppl 1:S21-S141
pubmed: 31710717
J Pharmacol Exp Ther. 2016 May;357(2):293-9
pubmed: 26941171
Am J Physiol Cell Physiol. 2001 Nov;281(5):C1614-23
pubmed: 11600425
Trends Biochem Sci. 2015 Oct;40(10):548-551
pubmed: 26410595
Physiol Rev. 1998 Jul;78(3):687-721
pubmed: 9674691
PLoS One. 2015 Aug 24;10(8):e0136632
pubmed: 26302445
Trends Pharmacol Sci. 1995 Feb;16(2):50-6
pubmed: 7762083
AMA Arch Ophthalmol. 1958 Nov;60(5):863-7
pubmed: 13582330
Surv Ophthalmol. 1970 Jan;14(4):330-5
pubmed: 4906586
Auton Neurosci. 2007 Dec 30;137(1-2):63-6
pubmed: 17804303
Mol Pharmacol. 2004 Aug;66(2):312-21
pubmed: 15266022
Br J Pharmacol. 2020 May;177(9):2090-2105
pubmed: 31901203
Biomol Concepts. 2018 Dec 26;9(1):143-154
pubmed: 30864350
Eur J Pharmacol. 2001 Mar 30;416(3):251-4
pubmed: 11290376