Preservation of Visual Cortex Plasticity in Retinitis Pigmentosa.
Retinitis Pigmentosa
plasticity
rd10 mouse model
visual cortex
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
10
06
2019
revised:
07
10
2019
accepted:
27
10
2019
entrez:
6
1
2020
pubmed:
7
1
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Retinitis Pigmentosa (RP) is a class of inherited disorders caused by the progressive death of photoreceptors in the retina. RP is still orphan of an effective treatment, with increasing optimism deriving from research aimed at arresting neurodegeneration or replacing light-responsive elements. All these therapeutic strategies rely on the functional integrity of the visual system downstream of photoreceptors. Whereas the inner retinal structure and optic radiation are known to be considerably preserved at least in early stages of RP, very little is known about the visual cortex. Remarkably, it remains completely unclear whether visual cortex plasticity is still present in RP. Using a well-established murine model of RP, the rd10 mouse, we report that visual cortical circuits retain high levels of plasticity, preserving their capability of input-dependent remodelling even at a late stage of retinal degeneration.
Identifiants
pubmed: 31901258
pii: S0306-4522(19)30744-4
doi: 10.1016/j.neuroscience.2019.10.045
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-210Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.