Panel 1: Biotechnology, biomedical engineering and new models of otitis media.
Animals
Artificial Intelligence
Biofilms
Biomedical Engineering
Biotechnology
Disease Models, Animal
Ear, Middle
/ diagnostic imaging
Haemophilus Infections
/ prevention & control
Haemophilus Vaccines
Haemophilus influenzae
Humans
Otitis Media
/ diagnosis
Otitis Media with Effusion
/ diagnostic imaging
Tympanic Membrane
/ diagnostic imaging
Animal model
Diagnostics
Haemophilus influenzae
Moraxella catarrhalis
Otitis media
Streptococcus pneumoniae
Treatment
Vaccines
Journal
International journal of pediatric otorhinolaryngology
ISSN: 1872-8464
Titre abrégé: Int J Pediatr Otorhinolaryngol
Pays: Ireland
ID NLM: 8003603
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
pubmed:
7
1
2020
medline:
17
9
2020
entrez:
6
1
2020
Statut:
ppublish
Résumé
To summarize recently published key articles on the topics of biomedical engineering, biotechnology and new models in relation to otitis media (OM). Electronic databases: PubMed, Ovid Medline, Cochrane Library and Clinical Evidence (BMJ Publishing). Articles on biomedical engineering, biotechnology, material science, mechanical and animal models in OM published between May 2015 and May 2019 were identified and subjected to review. A total of 132 articles were ultimately included. New imaging technologies for the tympanic membrane (TM) and the middle ear cavity are being developed to assess TM thickness, identify biofilms and differentiate types of middle ear effusions. Artificial intelligence (AI) has been applied to train software programs to diagnose OM with a high degree of certainty. Genetically modified mice models for OM have further investigated what predisposes some individuals to OM and consequent hearing loss. New vaccine candidates protecting against major otopathogens are being explored and developed, especially combined vaccines, targeting more than one pathogen. Transcutaneous vaccination against non-typeable Haemophilus influenzae has been successfully tried in a chinchilla model. In terms of treatment, novel technologies for trans-tympanic drug delivery are entering the clinical domain. Various growth factors and grafting materials aimed at improving healing of TM perforations show promising results in animal models. New technologies and AI applications to improve the diagnosis of OM have shown promise in pre-clinical models and are gradually entering the clinical domain. So are novel vaccines and drug delivery approaches that may allow local treatment of OM. New diagnostic methods, potential vaccine candidates and the novel trans-tympanic drug delivery show promising results, but are not yet adapted to clinical use.
Identifiants
pubmed: 31901291
pii: S0165-5876(19)30586-5
doi: 10.1016/j.ijporl.2019.109833
pmc: PMC7176743
mid: NIHMS1573427
pii:
doi:
Substances chimiques
Haemophilus Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
109833Subventions
Organisme : Department of Health
ID : NIHR-RP-011-045
Pays : United Kingdom
Organisme : NIDCD NIH HHS
ID : R01 DC000129
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012595
Pays : United States
Organisme : NIDCD NIH HHS
ID : R13 DC017389
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Ryan M. Nolan, is the Co-Founder and VP of Clinical Operations, PhotoniCare, Inc. Tal Marom and Anne G.M. Schilder are on the Scientific Advisory Board of Novus Therapeutics, Inc. Allen F. Ryan is a Co-founder of and stockholder in Otonomy, Inc. The other authors declare no conflicts of interest, and there has been no financial support received for this work. Funding for the generation and publication of this panel report was made possible in part by 1 R13 DC017389-01 from the National Institute on Deafness and Other Communication Disorders.
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