Cultivating Innovative Pragmatic Cluster-Randomized Registry Trials Embedded in Hemodialysis Care: Workshop Proceedings From 2018.

chronic kidney disease cluster randomized hemodialysis patient-oriented research pragmatic randomized controlled trial registry-based workshop

Journal

Canadian journal of kidney health and disease
ISSN: 2054-3581
Titre abrégé: Can J Kidney Health Dis
Pays: England
ID NLM: 101640242

Informations de publication

Date de publication:
2019
Historique:
received: 22 07 2019
accepted: 24 10 2019
entrez: 7 1 2020
pubmed: 7 1 2020
medline: 7 1 2020
Statut: epublish

Résumé

Hemodialysis is a life-sustaining treatment for persons with kidney failure. However, those on hemodialysis still face a poor quality of life and a short life expectancy. High-quality research evidence from large randomized controlled trials is needed to identify interventions that improve the experiences, outcomes, and health care of persons receiving hemodialysis. With the support of the Canadian Institutes of Health Research and its Strategy for Patient-Oriented Research, the Innovative Clinical Trials in Hemodialysis Centers initiative brought together Canadian and international kidney researchers, patients, health care providers, and health administrators to participate in a workshop held in Toronto, Canada, on June 2 and 3, 2018. The workshop served to increase knowledge and awareness about the conduct of innovative, pragmatic, cluster-randomized registry trials embedded into routine hemodialysis care and provided an opportunity to discuss and build support for new trial ideas. The workshop content included structured presentations, facilitated group discussions, and expert panel feedback. Partnerships and promising trial ideas borne out of the workshop will continue to be developed to support the implementation of future large-scale trials. L’hémodialyse constitue un traitement essentiel au maintien de la vie pour les personnes atteintes d’insuffisance rénale. Les patients hémodialysés voient cependant leur qualité et leur espérance de vie réduites. Des données de recherches probantes, provenant de vastes essais cliniques contrôlés à répartition aléatoire, sont nécessaires pour améliorer l’expérience, les résultats et les soins des patients hémodialysés. Grâce au soutien des Instituts de recherche en santé du Canada (IRSC) et de leur Stratégie de recherche axée sur le patient (SRAP), l’initiative sur les essais cliniques novateurs (ECN) en centres d’hémodialyse a réuni divers intervenants en santé rénale (chercheurs, patients, fournisseurs de soins et administrateurs), du Canada et de partout dans le monde, lors d’un colloque qui s’est tenu à Toronto les 2 et 3 juin 2018. Ce colloque a permis d’accroître la sensibilisation et les connaissances sur la conduite d’essais cliniques novateurs, répartis en grappes, pragmatiques et intégrés aux soins d’hémodialyse de routine. Cette rencontre a également fourni une occasion de discuter de nouvelles idées d’essais cliniques et de susciter les appuis nécessaires à leur réalisation. Le colloque s’est déroulé sous forme de présentations structurées, de discussions animées en groupe et de rétroaction de la part d’un comité d’experts. Les idées de recherche prometteuses et les partenariats issus de ce colloque continueront d’être développés pour soutenir la réalisation d’essais cliniques futurs de grande envergure.

Autres résumés

Type: Publisher (fre)
L’hémodialyse constitue un traitement essentiel au maintien de la vie pour les personnes atteintes d’insuffisance rénale. Les patients hémodialysés voient cependant leur qualité et leur espérance de vie réduites. Des données de recherches probantes, provenant de vastes essais cliniques contrôlés à répartition aléatoire, sont nécessaires pour améliorer l’expérience, les résultats et les soins des patients hémodialysés. Grâce au soutien des Instituts de recherche en santé du Canada (IRSC) et de leur Stratégie de recherche axée sur le patient (SRAP), l’initiative sur les essais cliniques novateurs (ECN) en centres d’hémodialyse a réuni divers intervenants en santé rénale (chercheurs, patients, fournisseurs de soins et administrateurs), du Canada et de partout dans le monde, lors d’un colloque qui s’est tenu à Toronto les 2 et 3 juin 2018. Ce colloque a permis d’accroître la sensibilisation et les connaissances sur la conduite d’essais cliniques novateurs, répartis en grappes, pragmatiques et intégrés aux soins d’hémodialyse de routine. Cette rencontre a également fourni une occasion de discuter de nouvelles idées d’essais cliniques et de susciter les appuis nécessaires à leur réalisation. Le colloque s’est déroulé sous forme de présentations structurées, de discussions animées en groupe et de rétroaction de la part d’un comité d’experts. Les idées de recherche prometteuses et les partenariats issus de ce colloque continueront d’être développés pour soutenir la réalisation d’essais cliniques futurs de grande envergure.

Identifiants

pubmed: 31903190
doi: 10.1177/2054358119894394
pii: 10.1177_2054358119894394
pmc: PMC6933546
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2054358119894394

Subventions

Organisme : NIDDK NIH HHS
ID : UH3 DK102384
Pays : United States

Informations de copyright

© The Author(s) 2019.

Déclaration de conflit d'intérêts

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Auteurs

Aakil Patel (A)

ICES, ON, Canada.

Rey R Acedillo (RR)

Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Jovina C Bachynski (JC)

Halton Healthcare Services, Oakville, ON, Canada.

Ian Barrett (I)

St. Michael's Hospital, Toronto, ON, Canada.

Erika Basile (E)

Office of Human Research Ethics, Western University, London, ON, Canada.

Marisa Battistella (M)

Department of Pharmacy, University Health Network, Toronto, ON, Canada.
Leslie Dan Faculty of Pharmacy, University of Toronto, ON, Canada.

Derek Benjamin (D)

Royal Victoria Regional Health Centre, Barrie, ON, Canada.

David Berry (D)

Algoma Regional Renal Program, Sault Area Hospital, Sault Ste. Marie, ON, Canada.

Peter G Blake (PG)

Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.
Ontario Renal Network, Cancer Care Ontario, Toronto, Canada.

Patricia Chan (P)

Division of Nephrology, Department of Medicine, Michael Garron Hospital, Toronto, ON, Canada.

Clara J Bohm (CJ)

Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada.

Kristin K Clemens (KK)

ICES, ON, Canada.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Division of Endocrinology and Metabolism, Department of Medicine, Western University, London, ON, Canada.
St. Joseph's Health Care London, ON, Canada.

Charles Cook (C)

Transplant Ambassador Program, Grand River Hospital, Kitchener, ON, Canada.

Laura Dember (L)

Renal, Electrolyte and Hypertension Division, Perelman School of Medicine, Philadelphia, PA, USA.

Jade S Dirk (JS)

ICES, ON, Canada.

Stephanie Dixon (S)

ICES, ON, Canada.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.

Elisabeth Fowler (E)

The Kidney Foundation of Canada, Montreal, QC, Canada.

Leah Getchell (L)

Can-SOLVE CKD Network, Vancouver, BC, Canada.

Nazanine Gholami (N)

St. Joseph's Health Centre, Toronto, ON, Canada.

Cory Goldstein (C)

Rotman Institute of Philosophy, Western University, London, ON, Canada.

Emma Hahn (E)

ICES, ON, Canada.

Betty Hogeterp (B)

Lakeridge Health Oshawa, ON, Canada.

Susan Huang (S)

Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.

Michelle Hughes (M)

Orillia Soldiers' Memorial Hospital, ON, Canada.

Meg J Jardine (MJ)

Innovation & Kidney Research, The George Institute for Global Health, UNSW Sydney, Newtown, NSW, Australia.

Shasikara Kalatharan (S)

Can-SOLVE CKD Network, Vancouver, BC, Canada.

Shane Kilburn (S)

ICES, ON, Canada.

Eduardo Lacson (E)

Tufts Medical Center, Boston, MA, USA.

Sean Leonard (S)

ICES, ON, Canada.

Channing Liberty (C)

The Ottawa Hospital, ON, Canada.

Craig Lindsay (C)

Scarborough Health Network, Toronto, ON, Canada.

Jennifer M MacRae (JM)

Division of Nephrology, Department of Medicine, University of Calgary, AB, Canada.

Braden J Manns (BJ)

Department of Medicine, Cumming School of Medicine, University of Calgary, AB, Canada.

Janice McCallum (J)

Ontario Renal Network, Cancer Care Ontario, Toronto, Canada.
Renal Services, London Health Sciences Centre, ON, Canada.

Christopher W McIntyre (CW)

Kidney Clinical Research Unit, Lawson Health Research Institute, London, ON, Canada.
Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Amber O Molnar (AO)

ICES, ON, Canada.
Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Reem A Mustafa (RA)

Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, USA.

Gihad E Nesrallah (GE)

Division of Nephrology, Department of Medicine, Humber River Hospital, Toronto, ON, Canada.

Matthew J Oliver (MJ)

Division of Nephrology, Department of Medicine, University of Toronto, ON, Canada.

Michael Pandes (M)

Mackenzie Health, Richmond Hill, ON, Canada.

Sanjay Pandeya (S)

Halton Healthcare, Oakville, ON, Canada.

Malvinder S Parmar (MS)

Kidney Care Centre, Timmins and District Hospital, ON, Canada.

Elijah Z Rabin (EZ)

Niagara Health System, St. Catharines, ON, Canada.

Johnathan Riley (J)

Ontario SPOR SUPPORT Unit, Toronto, ON, Canada.

Samuel A Silver (SA)

Division of Nephrology, Kingston Health Sciences Center, Queen's University, Kingston, ON, Canada.

Jessica M Sontrop (JM)

ICES, ON, Canada.
Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.
Kidney Clinical Research Unit, Lawson Health Research Institute, London, ON, Canada.

Manish M Sood (MM)

ICES, ON, Canada.
Division of Nephrology, Department of Medicine, University of Ottawa, ON, Canada.

Rita S Suri (RS)

Division of Nephrology, Department of Medicine, McGill University, Montreal, QC, Canada.
Canadian Nephrology Trials Network, Canada.

Navdeep Tangri (N)

Chronic Disease Innovation Centre, Winnipeg, MB, Canada.
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

Daniel J Tascona (DJ)

Ontario Renal Network, Cancer Care Ontario, Toronto, Canada.
Orillia Soldiers' Memorial Hospital, ON, Canada.

Alison Thomas (A)

St. Michael's Hospital, Toronto, ON, Canada.

Ron Wald (R)

St. Michael's Hospital, Toronto, ON, Canada.
Division of Nephrology, Department of Medicine, University of Toronto, ON, Canada.

Michael Walsh (M)

Division of Nephrology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Population Health Research Institute, Hamilton, ON, Canada.

Charles Weijer (C)

Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Rotman Institute of Philosophy, Western University, London, ON, Canada.

Matthew A Weir (MA)

ICES, ON, Canada.
Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.
Kidney Clinical Research Unit, Lawson Health Research Institute, London, ON, Canada.

Hans Vorster (H)

Ontario Renal Network, Cancer Care Ontario, Toronto, Canada.

Deborah Zimmerman (D)

Division of Nephrology, Department of Medicine, University of Ottawa, ON, Canada.

Amit X Garg (AX)

ICES, ON, Canada.
Division of Nephrology, Department of Medicine, London Health Sciences Centre, ON, Canada.
Department of Epidemiology and Biostatistics, Western University, London, ON, Canada.
Kidney Clinical Research Unit, Lawson Health Research Institute, London, ON, Canada.

Classifications MeSH