Persistent alterations in cerebrovascular reactivity in response to hypercapnia following pediatric mild traumatic brain injury.
Adolescent
Anxiety
/ epidemiology
Brain Concussion
/ complications
Carbon Dioxide
/ blood
Case-Control Studies
Cerebrovascular Circulation
/ physiology
Child
Female
Gray Matter
/ blood supply
Headache
/ epidemiology
Humans
Hypercapnia
/ blood
Male
Neuroimaging
/ methods
Pain
/ epidemiology
Post-Concussion Syndrome
/ diagnosis
Prospective Studies
Sleep Wake Disorders
/ epidemiology
White Matter
/ blood supply
Cerebral blood flow
cerebrovascular reactivity
concussion
functional magnetic resonance imaging
pediatric mild traumatic brain injury
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
7
1
2020
medline:
23
3
2021
entrez:
7
1
2020
Statut:
ppublish
Résumé
Much attention has been paid to the effects of mild traumatic brain injury (mTBI) on cerebrovascular reactivity in adult populations, yet it remains understudied in pediatric injury. In this study, 30 adolescents (12-18 years old) with pediatric mTBI (pmTBI) and 35 age- and sex-matched healthy controls (HC) underwent clinical and neuroimaging assessments during sub-acute (6.9 ± 2.2 days) and early chronic (120.4 ± 11.7 days) phases of injury. Relative to controls, pmTBI reported greater initial post-concussion symptoms, headache, pain, and anxiety, resolving by four months post-injury. Patients reported increased sleep issues and exhibited deficits in processing speed and attention across both visits. In grey-white matter interface areas throughout the brain, pmTBI displayed increased maximal fit/amplitude of a time-shifted end-tidal CO
Identifiants
pubmed: 31903838
doi: 10.1177/0271678X19896883
pmc: PMC7820694
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2491-2504Subventions
Organisme : NINDS NIH HHS
ID : R01 NS098494
Pays : United States
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