Synthesis and Structure-Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin.
Antitubercular Agents
/ chemical synthesis
Bacterial Proteins
/ antagonists & inhibitors
Enzyme Inhibitors
/ chemical synthesis
Microbial Sensitivity Tests
Molecular Structure
Mycobacterium tuberculosis
/ drug effects
Oligopeptides
/ chemical synthesis
Oxidoreductases
/ antagonists & inhibitors
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
13 02 2020
13 02 2020
Historique:
pubmed:
7
1
2020
medline:
4
8
2020
entrez:
7
1
2020
Statut:
ppublish
Résumé
A series of derivatives of the antimycobacterial natural product pyridomycin have been prepared with the C2 side chain attached to the macrocyclic core structure by a C-C single bond, in place of the synthetically more demanding enol ester double bond found in the natural product. Hydrophobic C2 substituents of sufficient size generally provide for potent
Identifiants
pubmed: 31904960
doi: 10.1021/acs.jmedchem.9b01457
doi:
Substances chimiques
Antitubercular Agents
0
Bacterial Proteins
0
Enzyme Inhibitors
0
Oligopeptides
0
Oxidoreductases
EC 1.-
InhA protein, Mycobacterium
EC 1.3.1.9
pyridomycin
ZTB2215O45
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM