Neuron-Like Cells Generated from Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells as a New In Vitro Model for Neuronal Toxicity Screening: Using Magnetite Nanoparticles as an Example.
Fe3O4 nanoparticles
alternative methods
cell-based assay
environmental toxicology
human primary cell culture
predictive nanotoxicology
safety assessment
toxicity-testing strategies
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Dec 2019
31 Dec 2019
Historique:
received:
27
11
2019
revised:
20
12
2019
accepted:
29
12
2019
entrez:
8
1
2020
pubmed:
8
1
2020
medline:
14
5
2020
Statut:
epublish
Résumé
The wide employment of iron nanoparticles in environmental and occupational settings underlines their potential to enter the brain. Human cell-based systems are recommended as relevant models to reduce uncertainty and to improve prediction of human toxicity. This study aimed at demonstrating the in vitro differentiation of the human umbilical cord lining-derived-mesenchymal stem cells (hCL-MSCs) into neuron-like cells (hNLCs) and the benefit of using them as an ideal primary cell source of human origin for the neuronal toxicity of Fe
Identifiants
pubmed: 31906090
pii: ijms21010271
doi: 10.3390/ijms21010271
pmc: PMC6982086
pii:
doi:
Substances chimiques
Magnetite Nanoparticles
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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