The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses.

A549 Cells Amino Acid Substitution Animals Dogs Female Humans Influenza A Virus, H1N1 Subtype / genetics Madin Darby Canine Kidney Cells Mice Mice, Inbred BALB C Orthomyxoviridae Infections / pathology RNA-Dependent RNA Polymerase / genetics Viral Proteins / genetics Virulence / genetics Virus Replication / genetics
Eurasian avian-like H1N1 swine influenza viruses PB2 gene PB2-R251K pathogenicity polymerase

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
02 01 2020
Historique:
received: 27 11 2019
revised: 29 12 2019
accepted: 31 12 2019
entrez: 8 1 2020
pubmed: 8 1 2020
medline: 7 2 2021
Statut: epublish

Résumé

The Eurasian avian-like swine (EA) H1N1 virus has affected the Chinese swine industry, and human infection cases have been reported occasionally. However, little is known about the pathogenic mechanism of EA H1N1 virus. In this study, we compared the mouse pathogenicity of A/swine/Guangdong/YJ4/2014 (YJ4) and A/swine/Guangdong/MS285/2017 (MS285) viruses, which had similar genotype to A/Hunan/42443/2015 (HuN-like). None of the mice inoculated with 10

Identifiants

DOI: 10.3390/v12010052 PMID: 31906472 PMC: PMC7019279
pubmed: 31906472
pii: v12010052
doi: 10.3390/v12010052
pmc: PMC7019279
pii:
doi:

Substances chimiques

PB2 protein, Influenzavirus A 0
Viral Proteins 0
RNA-Dependent RNA Polymerase EC 2.7.7.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

Mengkai Cai (M)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Ruting Zhong (R)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510462, China.

Chenxiao Qin (C)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Zhiqing Yu (Z)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Xiaoyan Wen (X)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Junsi Xian (J)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Yongjie Chen (Y)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Yu Cai (Y)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Heyou Yi (H)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Lang Gong (L)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

Guihong Zhang (G)

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510462, China.
Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, South China Agricultural University, Guangzhou 510462, China.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules A549 › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Eucaryotes › Animaux › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Pinnipedia › Canidae › Chiens › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H1N1 du virus de la grippe A › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules rénales canines Madin-Darby › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Orthomyxoviridae › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA replicase › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Phénomènes microbiologiques › Virulence › The R251K Substitution in Viral Protein PB2...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › The R251K Substitution in Viral Protein PB2...