Sex Disparity in Response to Hepatitis B Vaccine Related to the Age of Vaccination.
HBs-antibodies
gender
health care workers
hepatitis B
sex
vaccine
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
02 01 2020
02 01 2020
Historique:
received:
22
11
2019
revised:
24
12
2019
accepted:
31
12
2019
entrez:
8
1
2020
pubmed:
8
1
2020
medline:
15
8
2020
Statut:
epublish
Résumé
Hepatitis B virus (HBV) infection is one of the major infectious hazards for health-care workers (HCWs) because of the frequency of percutaneous exposures to blood or body fluids. For this reason, all HCWs should be vaccinated, including students in medicine and health professional degree programs. The aim of this study was to assess the immune coverage to anti-HBV vaccine and long-lasting protective titres of anti-HBs antibodies in female and male students to evaluate gender-related differences in response to HBV vaccination. Data relative to anti-HBs antibody titre, sex, age, and age at vaccination were collected and analyzed from 5291 Italian students (1812 males and 3479 females) of the graduate courses at the School of Medicine, who underwent the mandatory health surveillance of workers exposed to biological risk. The results indicated that gender affects the immune response to HBV vaccine, particularly evident in the case of females vaccinated after one year of age who exhibited a statistically significant (
Identifiants
pubmed: 31906550
pii: ijerph17010327
doi: 10.3390/ijerph17010327
pmc: PMC6981715
pii:
doi:
Substances chimiques
Hepatitis B Antibodies
0
Hepatitis B Surface Antigens
0
Hepatitis B Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
ScientificWorldJournal. 2014;2014:159150
pubmed: 25478584
Indian Pediatr. 2004 Dec;41(12):1232-7
pubmed: 15623904
Lancet Infect Dis. 2010 May;10(5):338-49
pubmed: 20417416
J Immunol. 2017 Mar 1;198(5):1782-1790
pubmed: 28223406
Ann Agric Environ Med. 2017 Jun 12;24(2):303-306
pubmed: 28664713
World J Hepatol. 2016 Feb 18;8(5):273-81
pubmed: 26925201
Eur J Public Health. 2011 Jun;21(3):338-43
pubmed: 20817688
Brain Behav Immun. 2008 May;22(4):503-16
pubmed: 18053684
J Genomics. 2014 Apr 01;2:77-88
pubmed: 25031659
Ann Ist Super Sanita. 2016 Apr-Jun;52(2):198-204
pubmed: 27364394
Endocrinology. 2012 Jun;153(6):2544-50
pubmed: 22434079
Aging Cell. 2015 Jun;14(3):309-21
pubmed: 25720438
Trans R Soc Trop Med Hyg. 2015 Jan;109(1):9-15
pubmed: 25573105
Arch Intern Med. 2008 Dec 8;168(22):2405-14
pubmed: 19064822
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):869-74
pubmed: 24367114
Hum Vaccin Immunother. 2019 Sep 5;:1-5
pubmed: 31487228
Lancet. 2005 Oct 15-21;366(9494):1379-84
pubmed: 16226616
Nat Rev Immunol. 2008 Sep;8(9):737-44
pubmed: 18728636
Hum Vaccin Immunother. 2015;11(11):2522-37
pubmed: 26291642
Vaccine. 2013 Mar 25;31(13):1696-700
pubmed: 23384750