Deep and Densely Connected Networks for Classification of Diabetic Retinopathy.

convolutional neural networks deep learning densely connected networks diabetic retinopathy fundus image analysis healthcare diagnosis

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
02 Jan 2020
Historique:
received: 11 11 2019
revised: 17 12 2019
accepted: 23 12 2019
entrez: 8 1 2020
pubmed: 8 1 2020
medline: 8 1 2020
Statut: epublish

Résumé

Diabetes has recently emerged as a worldwide problem, and diabetic retinopathy is an abnormal state associated with the human retina. Due to the increase in daily screen-related activities of modern human beings, diabetic retinopathy is more prevalent among adults, leading to minor and major blindness. Doctors and clinicians are unable to perform early diagnoses due to the large number of patients. To solve this problem, this study introduces a classification model for retinal images that distinguishes between the various stages of diabetic retinopathy. This work involves deploying deep and densely connected networks for retinal image analysis with training from scratch. Dense connections between the convolutional layers of the network are an essential factor to enhance accuracy owing to the deeper supervision between layers. Another factor is the growth rate that further assists our model in learning more sophisticated feature maps regarding retinal images from every stage of the network. We compute the area under the curve, sensitivity, and specificity, particularly for messidor-2 and EyePACS. Compared to existing approaches, our method achieved better results, with an approximate rise rate of 0.01, 0.03, and 0.01, respectively. Therefore, computer-aided programs can help in diagnostic centers as automated detection systems.

Identifiants

pubmed: 31906601
pii: diagnostics10010024
doi: 10.3390/diagnostics10010024
pmc: PMC7169456
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Research Foundation of Korea
ID : 2017M3A9E2056461
Organisme : National Research Foundation of Korea
ID : 2018R1D1A1B07048264

Références

IEEE Trans Med Imaging. 2018 May;37(5):1149-1161
pubmed: 29727278
Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2861-2868
pubmed: 30025129
Trends Biotechnol. 2015 Nov;33(11):692-705
pubmed: 26463722
IEEE Rev Biomed Eng. 2010;3:169-208
pubmed: 22275207
Nat Biomed Eng. 2018 Mar;2(3):158-164
pubmed: 31015713
Diabetes Care. 2012 Mar;35(3):556-64
pubmed: 22301125
Med Image Anal. 2017 Dec;42:60-88
pubmed: 28778026
Ophthalmology. 2019 Apr;126(4):552-564
pubmed: 30553900
Comput Biol Med. 2013 Dec;43(12):2136-55
pubmed: 24290931
AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:147-155
pubmed: 29888061
Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):590-596
pubmed: 29372258
PLoS One. 2017 Nov 2;12(11):e0187336
pubmed: 29095872
JAMA. 2017 Dec 12;318(22):2211-2223
pubmed: 29234807
JAMA. 2016 Dec 13;316(22):2402-2410
pubmed: 27898976
Ophthalmic Epidemiol. 2007 Jul-Aug;14(4):179-83
pubmed: 17896294
IEEE Trans Neural Netw. 1994;5(2):157-66
pubmed: 18267787
IEEE Trans Biomed Eng. 2018 Mar;65(3):608-618
pubmed: 28541892

Auteurs

Hamza Riaz (H)

Department of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Incheon 21999, Korea.

Jisu Park (J)

Department of Health Science and Technology, Gachon Advanced Institute for Health Sciences & Technology, Incheon 21999, Korea.

Hojong Choi (H)

Department of Medical IT Convergence Engineering, Kumoh National Institute of Technology, 350-27, Gum-daero, Gumi 39253, Korea.

Hyunchul Kim (H)

School of Information, University of California, 102 South Hall #4600, Berkeley, CA 94720, USA.

Jungsuk Kim (J)

Department of Biomedical Engineering, Gachon University, 534-2, Hambakmoe-ro, Incheon 21936, Korea.

Classifications MeSH