High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children.
Antimalarials
/ administration & dosage
Child
Child, Preschool
Chloroquine
/ administration & dosage
Dose-Response Relationship, Drug
Drug Resistance
/ genetics
Electrocardiography
Female
Gene Expression
Guinea-Bissau
Humans
Long QT Syndrome
/ chemically induced
Malaria, Falciparum
/ drug therapy
Male
Membrane Transport Proteins
/ genetics
Parasite Load
Plasmodium falciparum
/ drug effects
Protozoan Proteins
/ genetics
Treatment Outcome
Guinea-Bissau
Plasmodium falciparum
cardiac safety
chloroquine
pfcrt
pharmacokinetics
tolerability
treatment
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
10
09
2019
accepted:
20
12
2019
pubmed:
8
1
2020
medline:
19
12
2020
entrez:
8
1
2020
Statut:
epublish
Résumé
Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by
Identifiants
pubmed: 31907183
pii: AAC.01846-19
doi: 10.1128/AAC.01846-19
pmc: PMC7038251
pii:
doi:
Substances chimiques
Antimalarials
0
Membrane Transport Proteins
0
PfCRT protein, Plasmodium falciparum
0
Protozoan Proteins
0
Chloroquine
886U3H6UFF
Banques de données
ClinicalTrials.gov
['NCT01814423']
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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