The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance.

Aging / metabolism Animals Autophagy Beclin-1 / deficiency Female Glucuronidase / genetics HEK293 Cells Humans Kidney / metabolism Klotho Proteins Male Mice Phosphates / metabolism Protein Binding Proto-Oncogene Proteins c-bcl-2 / metabolism
BCL2 NaPi cotransporter aging autophagy beclin 1 fertility longevity phosphorus phosphotoxicity αKlotho

Journal

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484

Informations de publication

Date de publication:
02 2020
Historique:
received: 22 08 2019
revised: 19 12 2019
accepted: 19 12 2019
pubmed: 8 1 2020
medline: 7 10 2020
entrez: 8 1 2020
Statut: ppublish

Résumé

Aging-related organ degeneration is driven by multiple factors including the cell maintenance mechanisms of autophagy, the cytoprotective protein αKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity. To examine the interplay between Pi, autophagy, and αKlotho, we used the BK/BK mouse (homozygous for mutant Becn1

Identifiants

DOI: 10.1096/fj.201902127R PMID: 31908069 PMC: PMC7286356
pubmed: 31908069
doi: 10.1096/fj.201902127R
pmc: PMC7286356
mid: NIHMS1584400
doi:

Substances chimiques

Beclin-1 0
Becn1 protein, mouse 0
Phosphates 0
Proto-Oncogene Proteins c-bcl-2 0
Bcl2 protein, mouse 114100-40-2
Glucuronidase EC 3.2.1.31
Klotho Proteins EC 3.2.1.31

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3129-3150

Subventions

Organisme : UT Southwestern Medical Center O'Brien Kidney Research Center
ID : P30-DK07938
Pays : International
Organisme : UT Southwestern Medical Center O'Brien Kidney Research Center
ID : U19AI199725
Pays : International
Organisme : NIH HHS
ID : S10 OD021684
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091392
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA109618
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK092461
Pays : United States

Informations de copyright

© 2020 Federation of American Societies for Experimental Biology.

Références

J Bone Miner Metab. 2012 Jan;30(1):10-8
pubmed: 22219005
Sci Rep. 2017 Aug 10;7(1):7786
pubmed: 28798354
Pflugers Arch. 2009 May;458(1):39-52
pubmed: 18758808
Kidney Dis (Basel). 2017 Jul;3(1):15-23
pubmed: 28785560
J Am Soc Nephrol. 2016 Jan;27(1):79-90
pubmed: 25977312
Nature. 1997 Nov 6;390(6655):45-51
pubmed: 9363890
J Am Soc Nephrol. 2015 Jun;26(6):1290-302
pubmed: 25326585
Nat Rev Nephrol. 2014 May;10(5):268-78
pubmed: 24686452
FASEB J. 2010 Sep;24(9):3562-71
pubmed: 20418498
Kidney Int. 2017 May;91(5):1070-1087
pubmed: 28139295
Nat Rev Mol Cell Biol. 2018 Sep;19(9):579-593
pubmed: 30006559
Mech Ageing Dev. 2010 Apr;131(4):270-5
pubmed: 20197072
Nephrol Dial Transplant. 2001 Feb;16(2):378-82
pubmed: 11158416
J Lipid Res. 1991 Oct;32(10):1539-70
pubmed: 1797938
Curr Opin Nephrol Hypertens. 2014 Jul;23(4):331-9
pubmed: 24867676
J Clin Invest. 2003 Dec;112(12):1809-20
pubmed: 14638851
Clin J Am Soc Nephrol. 2016 Jun 6;11(6):1088-100
pubmed: 26912542
Pediatr Nephrol. 2019 Apr;34(4):549-559
pubmed: 29275531
J Endocrinol Invest. 2014 Nov;37(11):1121-6
pubmed: 25194425
J Cell Mol Med. 2004 Apr-Jun;8(2):191-200
pubmed: 15256067
Med Clin North Am. 2017 Jan;101(1):81-101
pubmed: 27884238
Nat Cell Biol. 2011 Apr;13(4):342-4
pubmed: 21460804
Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1465-F1477
pubmed: 30089035
Kidney Int. 2017 May;91(5):1003-1005
pubmed: 28407874
PLoS Genet. 2017 Aug 14;13(8):e1006962
pubmed: 28806762
Trends Cell Biol. 1994 Apr;4(4):139-43
pubmed: 14731737
Nat Rev Nephrol. 2019 Jan;15(1):27-44
pubmed: 30455427
Sci Rep. 2018 Jan 8;8(1):9
pubmed: 29311680
Kidney Int. 2013 Jun;83(6):984-6
pubmed: 23727998
Am J Clin Nutr. 2014 Feb;99(2):320-7
pubmed: 24225358
Lancet. 2013 Jul 27;382(9889):339-52
pubmed: 23727170
Kidney Int. 2017 May;91(5):1104-1114
pubmed: 28131398
Mol Biol Cell. 2000 Jan;11(1):255-68
pubmed: 10637306
Pflugers Arch. 2019 Jan;471(1):99-108
pubmed: 30506274
Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4176-4181
pubmed: 29610308
Nature. 2013 Feb 14;494(7436):201-6
pubmed: 23364696
J Vasc Surg. 2015 Jul;62(1):210-221.e2
pubmed: 24797554
PLoS One. 2017 Sep 8;12(9):e0181848
pubmed: 28886014
Lab Invest. 2018 Aug;98(8):1105-1121
pubmed: 29858580
Nature. 2018 Jan 25;553(7689):461-466
pubmed: 29342138
Nephrol Dial Transplant. 2010 Sep;25(9):2938-44
pubmed: 20368307
Cell Res. 2014 Jan;24(1):24-41
pubmed: 24366339
Nat Genet. 2000 Nov;26(3):345-8
pubmed: 11062477
FEBS Lett. 2009 Oct 6;583(19):3221-4
pubmed: 19737556
Eur J Pharmacol. 2013 Jan 5;698(1-3):67-73
pubmed: 23041151
J Am Soc Nephrol. 2016 Sep;27(9):2810-24
pubmed: 26872488
Annu Rev Physiol. 2013;75:503-33
pubmed: 23398153
PLoS One. 2012;7(7):e39229
pubmed: 22859939
J Am Chem Soc. 2017 Jun 14;139(23):7792-7802
pubmed: 28414223
Nat Rev Nephrol. 2017 Feb;13(2):115-131
pubmed: 27990015
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19796-801
pubmed: 18056631
J Biol Chem. 2006 Mar 10;281(10):6120-3
pubmed: 16436388
J Nutr. 2001 Dec;131(12):3182-8
pubmed: 11739863
Circulation. 2004 Apr 13;109(14):1776-82
pubmed: 15037532
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):407-12
pubmed: 19966287
Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F501-F516
pubmed: 29187371
Circ Cardiovasc Genet. 2009 Dec;2(6):583-90
pubmed: 20031638
Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5
pubmed: 24778222
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15077-82
pubmed: 14657337
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20364-71
pubmed: 24277826
Bone. 2017 Jul;100:41-49
pubmed: 28115282
Kidney Int. 2013 Jun;83(6):1042-51
pubmed: 23364520
Curr Biol. 2002 Apr 30;12(9):R328-30
pubmed: 12007435
FASEB J. 2010 Sep;24(9):3438-50
pubmed: 20466874
J Gene Med. 2000 Jul-Aug;2(4):233-42
pubmed: 10953914
J Am Soc Nephrol. 2016 Aug;27(8):2331-45
pubmed: 26701976
PLoS One. 2013 Sep 10;8(9):e74996
pubmed: 24040373
Sci Rep. 2018 Sep 20;8(1):14133
pubmed: 30237523
Obstet Gynecol Clin North Am. 2015 Mar;42(1):15-25
pubmed: 25681837
Kidney Int. 2010 Dec;78(12):1240-51
pubmed: 20861825
Nature. 2006 Dec 7;444(7120):770-4
pubmed: 17086194
J Am Soc Nephrol. 2011 Jan;22(1):124-36
pubmed: 21115613
Nat Commun. 2013;4:2300
pubmed: 23939249
Nature. 2012 Jan 18;481(7382):511-5
pubmed: 22258505
Nat Rev Mol Cell Biol. 2007 Sep;8(9):681-91
pubmed: 17684529
J Clin Invest. 2011 Nov;121(11):4393-408
pubmed: 21985788
J Biol Chem. 2001 Jul 20;276(29):26906-15
pubmed: 11328806
Autophagy. 2016 Oct 2;12(10):1954-1955
pubmed: 27485905
Annu Rev Physiol. 2013;75:535-50
pubmed: 23398154
Sci Rep. 2015 Dec 17;5:18311
pubmed: 26674602
Curr Opin Nephrol Hypertens. 2006 Jul;15(4):437-41
pubmed: 16775459
Science. 2005 Sep 16;309(5742):1829-33
pubmed: 16123266
Nephrol Dial Transplant. 2015 Feb;30(2):223-33
pubmed: 25324355
J Am Soc Nephrol. 2014 Dec;25(12):2730-9
pubmed: 24854273
Nature. 2018 Jun;558(7708):136-140
pubmed: 29849149
Autophagy. 2018;14(4):717-718
pubmed: 29368986
BMC Nephrol. 2018 Feb 27;19(1):45
pubmed: 29486729

Auteurs

Mingjun Shi (M)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Jenny Maique (J)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Joy Shaffer (J)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Taylor Davidson (T)

Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Salwa Sebti (S)

Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Álvaro F Fernández (ÁF)

Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Zhongju Zou (Z)

Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Shirley Yan (S)

Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Beth Levine (B)

Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Center for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Departments of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Orson W Moe (OW)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Departments of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Ming Chang Hu (MC)

Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › The tripartite interaction of phosphate,...
questionsmedicales.fr › Eucaryotes › Animaux › The tripartite interaction of phosphate,...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › The tripartite interaction of phosphate,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Bécline-1 › The tripartite interaction of phosphate,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucuronidase › The tripartite interaction of phosphate,...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › The tripartite interaction of phosphate,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The tripartite interaction of phosphate,...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › The tripartite interaction of phosphate,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteur facteur croissance fibroblaste › Protéines Klotho › The tripartite interaction of phosphate,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The tripartite interaction of phosphate,...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › The tripartite interaction of phosphate,...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › The tripartite interaction of phosphate,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcl-2 › The tripartite interaction of phosphate,...