Low-Level Radiofrequency Exposure Does Not Induce Changes in MSC Biology: An in vitro Study for the Prevention of NIR-Related Damage.
169 MHz
CFU
senescence
stem cell
Journal
Stem cells and cloning : advances and applications
ISSN: 1178-6957
Titre abrégé: Stem Cells Cloning
Pays: New Zealand
ID NLM: 101535817
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
02
2019
accepted:
10
07
2019
entrez:
8
1
2020
pubmed:
8
1
2020
medline:
8
1
2020
Statut:
epublish
Résumé
The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation. The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30-300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity. The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G "Smart Meter" for different durations of time. We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments. We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.
Sections du résumé
BACKGROUND
BACKGROUND
The ubiquitous diffusion of radiofrequency (RF) radiation across human living environments has attracted the attention of scientists. Though the adverse health effects of RF exposure remain debatable, it has been reported that the interaction of such radiation with biological macromolecular structures can be deleterious for stem cells, inducing impairment of their main functions involving self-renewal and differentiation.
PURPOSE
OBJECTIVE
The purpose of this study was to determine whether exposure to RF of 169 megahertz (MHz) that is part of very high radiofrequency (VHF) range 30-300 MHz, could cause damage to stem cells by inducing senescence and loss of regenerative and DNA repair capacity.
METHODS
METHODS
The study was conducted on mesenchymal stromal cells (MSCs) containing a subpopulation of stem cells. The MSCs were exposed to RFs of 169 MHz administered via an open meter 2G "Smart Meter" for different durations of time.
RESULT
RESULTS
We did not observe modifications in MSC biology as a result of the RF exposure conducted in our experiments.
CONCLUSION
CONCLUSIONS
We concluded that MSCs are insensitive to RF radiation exposure at 169 MHz for various time intervals, including longer durations.
Identifiants
pubmed: 31908499
doi: 10.2147/SCCAA.S204166
pii: 204166
pmc: PMC6927227
doi:
Types de publication
Journal Article
Langues
eng
Pagination
49-59Informations de copyright
© 2019 Alessio et al.
Déclaration de conflit d'intérêts
Massimo Briccola, Paolo Giubbini, and Raffaella Marchesani were employed by e-distribuzione SpA at the time of the study. The authors report no other conflicts of interest in this work.
Références
Int J Radiat Biol. 2010 May;86(5):345-57
pubmed: 20397839
Electromagn Biol Med. 2017;36(3):295-305
pubmed: 28777669
Surg Today. 2014 Jun;44(6):985-91
pubmed: 23728491
Glycobiology. 2013 Dec;23(12):1463-76
pubmed: 24013961
Radiat Res. 2010 Aug;174(2):169-76
pubmed: 20681783
Radiology. 2018 Nov;289(2):317-324
pubmed: 30129904
Mol Vis. 2008 May 19;14:964-9
pubmed: 18509546
Electromagn Biol Med. 2016;35(2):186-202
pubmed: 26151230
J Cell Sci. 2011 Jan 1;124(Pt 1):68-81
pubmed: 21118958
Cancer Biol Ther. 2014 Jun 1;15(6):735-41
pubmed: 24618825
Clin Radiol. 2016 Sep;71(9):939.e1-8
pubmed: 27157314
Arrhythm Electrophysiol Rev. 2018 Jun;7(2):128-134
pubmed: 29967685
J Chem Neuroanat. 2016 Sep;75(Pt B):116-22
pubmed: 26775760
Stem Cell Reports. 2016 Jun 14;6(6):897-913
pubmed: 27304917
Nat Genet. 2001 Mar;27(3):247-54
pubmed: 11242102
Int J Environ Health Res. 2012;22(5):458-67
pubmed: 22369506
Cell Transplant. 2016;25(5):829-48
pubmed: 26423725
Neurotoxicology. 2007 Mar;28(2):434-40
pubmed: 16962663
Bioelectromagnetics. 2004 Sep;25(6):441-51
pubmed: 15300730
Stem Cells Transl Med. 2012 Sep;1(9):651-7
pubmed: 23197871
PLoS One. 2013 Apr 22;8(4):e61661
pubmed: 23613896
J Radiat Res. 2017 Nov 1;58(6):782-790
pubmed: 28595296
Environ Mol Mutagen. 2001;37(3):241-83
pubmed: 11317342
Reproduction. 2016 Dec;152(6):R263-R276
pubmed: 27601711
Stem Cells. 2018 Aug;36(8):1146-1153
pubmed: 29664142
Am J Clin Dermatol. 2018 Aug;19(4):459-477
pubmed: 29744784
Environ Res. 2019 Apr;171:581-592
pubmed: 30448205
Oncol Lett. 2018 May;15(5):7871-7883
pubmed: 29725476
J Cell Physiol. 2018 Nov;233(11):8996-9006
pubmed: 29904927
Mutat Res. 2010 Jan 5;683(1-2):35-42
pubmed: 19822160
Apoptosis. 2012 Sep;17(9):964-74
pubmed: 22684843
Dan Med J. 2015 May;62(5):null
pubmed: 26050823
Lancet Oncol. 2011 Jul;12(7):624-6
pubmed: 21845765
Int J Epidemiol. 2010 Jun;39(3):675-94
pubmed: 20483835
J Food Sci. 2015 Dec;80(12):C2732-9
pubmed: 26579996
Nature. 2001 May 17;411(6835):366-74
pubmed: 11357144
Clin Plast Surg. 2018 Oct;45(4):571-584
pubmed: 30268243
Int J Hyg Environ Health. 2008 Mar;211(1-2):1-29
pubmed: 17692567
Mutat Res. 2005 Jun 6;583(2):178-83
pubmed: 15869902
Cancer Biol Ther. 2009 Jul;8(13):1300-6
pubmed: 19458492
Int J Hyperthermia. 2017 Mar;33(2):122-134
pubmed: 27575391
Sci Rep. 2017 Dec 13;7(1):17541
pubmed: 29235463