An incidental finding in newborn screening leading to the diagnosis of a patient with

2-methyl-2,3-dihydroxybutyric acid 3-hydroxy-butyrylcarnitine\3-hydoxy-isobutyrylcarnitine 3MGA, 3-methylglutaconic acid C3DC, malonylcarnitine C4OH, 3-hydroxy-butyrylcarnitine\3-hydoxy-isobutyrylcarnitine C5:1, tiglylcarnitine DBS, dried blood spot DUS, dried urine spot ECHS1 deficiency ECHS1, short-chain enoyl-CoA hydratase GC, gas chromatography HIBCH, 3-hydroxy-isobutyryl-CoA hydrolase MRI, magnetic resonance imaging MS, mass spectrometry Mutations in ECHS1 NBS, Newborn Screening Newborn screening PDH, pyruvate dehydrogenase TMS, trimethylsilyl Tiglylcarnitine

Journal

Molecular genetics and metabolism reports
ISSN: 2214-4269
Titre abrégé: Mol Genet Metab Rep
Pays: United States
ID NLM: 101624422

Informations de publication

Date de publication:
Mar 2020
Historique:
received: 10 10 2019
revised: 16 12 2019
accepted: 17 12 2019
entrez: 8 1 2020
pubmed: 8 1 2020
medline: 8 1 2020
Statut: epublish

Résumé

Short-chain enoyl-CoA hydratase (ECHS1) is a mitochondrial beta-oxidation enzyme involved in the metabolism of acyl-CoA fatty acid esters, as well as in valine metabolism. ECHS1 deficiency has multiple manifestations, including Leigh syndrome early at birth or in childhood with poor prognosis, to cutis laxa, exercise-induced dystonia and congenital lactic acidosis. Here we describe the case of a newborn with mutations in ECHS1 that caught our attention after the incidental finding of 3-hydroxy-butyryl\3-hydroxy-isobutyryl\malonylcarnitine (C4OH\C3DC) and tiglylcarnitine (C5:1) on blood spot in the newborn screening (NBS) program. Diagnosis was suspected based on the analysis of organic acids on dried urine spot. A moderate increase of 2-methyl-2,3-dihydroxybutyric acid, was detected, which is a known marker of this disease. Exome analysis showed c.404A>G (p.Asn135Ser) mutation in homozygosis in the

Identifiants

pubmed: 31908952
doi: 10.1016/j.ymgmr.2019.100553
pii: S2214-4269(19)30185-5
pii: 100553
pmc: PMC6940607
doi:

Types de publication

Case Reports

Langues

eng

Pagination

100553

Informations de copyright

© 2019 Published by Elsevier Inc.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to disclose.

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Auteurs

S Pajares (S)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

R M López (RM)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

L Gort (L)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

A Argudo-Ramírez (A)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

J L Marín (JL)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

J M González de Aledo-Castillo (JM)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

J García-Villoria (J)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

J A Arranz (JA)

Metabolic Laboratory and Neuropediatric Service, Hospital Universitario Vall de Hebron, Barcelona, Spain.

M Del Toro (M)

Metabolic Laboratory and Neuropediatric Service, Hospital Universitario Vall de Hebron, Barcelona, Spain.

F Tort (F)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

O Ugarteburu (O)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

M D Casellas (MD)

Pediatric Service, Hospital Universitario Dr. Josep Trueta, Gerona, Spain.

R Fernández (R)

Public Health Agency, Health Department of Generalitat of Catalonia, Spain.

A Ribes (A)

Section of Inborn Errors of Metabolism, Department of Biochemistry and Molecular Genetics, Hospital Clínic, IDIBAPS, CIBERER, Barcelona, Spain.

Classifications MeSH