Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.
Aging
Alzheimer's disease
Memory
Neurodegeneration
β-amyloid
Journal
Alzheimer's & dementia (Amsterdam, Netherlands)
ISSN: 2352-8729
Titre abrégé: Alzheimers Dement (Amst)
Pays: United States
ID NLM: 101654604
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
8
1
2020
pubmed:
8
1
2020
medline:
8
1
2020
Statut:
epublish
Résumé
Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether "SuperAgers" may be protected from Aβ-associated neurodegeneration. Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older adults from the Australian Imaging, Biomarkers and Lifestyle study were case matched. Rates of cortical atrophy over 8 years were examined by SuperAger classification and Aβ status. Of the case-matched SuperAgers and cognitively normal for age older adults, 40.7% and 40.1%, respectively, were Aβ+. Rates of age- and Aβ-associated atrophy did not differ between the groups on any measure. Aβ- individuals displayed the slowest rates of atrophy. Maintenance of superior memory in late life does not reflect resistance to age- or Aβ-associated atrophy. However, those individuals who reached old age without cognitive impairment nor elevated Aβ deposition (i.e. Aβ-) displayed reduced rates of cortical atrophy.
Identifiants
pubmed: 31909172
doi: 10.1016/j.dadm.2019.05.005
pii: S2352-8729(19)30044-2
pmc: PMC6939054
doi:
Types de publication
Journal Article
Langues
eng
Pagination
566-575Investigateurs
Brian Chambers
(B)
Edmond Chiu
(E)
Roger Clarnette
(R)
David Darby
(D)
Mary Davison
(M)
John Drago
(J)
Peter Drysdale
(P)
Jacqueline Gilbert
(J)
Kwang Lim
(K)
Nicola Lautenschlager
(N)
Dina LoGiudice
(D)
Peter McCardle
(P)
Steve McFarlane
(S)
Alastair Mander
(A)
John Merory
(J)
Daniel O'Connor
(D)
Ron Scholes
(R)
Mathew Samuel
(M)
Darshan Trivedi
(D)
Michael Woodward
(M)
Informations de copyright
© 2019 The Authors.
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