Web-ARM: A Web-Based Interface for the Automatic Construction of QM/MM Models of Rhodopsins.


Journal

Journal of chemical information and modeling
ISSN: 1549-960X
Titre abrégé: J Chem Inf Model
Pays: United States
ID NLM: 101230060

Informations de publication

Date de publication:
23 03 2020
Historique:
pubmed: 8 1 2020
medline: 22 6 2021
entrez: 8 1 2020
Statut: ppublish

Résumé

This article introduces Web-ARM, a specialized tool, online available, designed to build quantum mechanical/molecular mechanical models of rhodopsins, a widely spread family of light-responsive proteins. Web-ARM allows the rapidly building of models of rhodopsins with a documented quality and the prediction of trends in UV-vis absorption maximum wavelengths, based on their excitation energies computed at the CASPT2//CASSCF/Amber level of theory. Web-ARM builds upon the recently reported, python-based

Identifiants

pubmed: 31909998
doi: 10.1021/acs.jcim.9b00615
pmc: PMC7101466
mid: NIHMS1560632
doi:

Substances chimiques

Rhodopsin 9009-81-8

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1481-1493

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM126627
Pays : United States

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Auteurs

Laura Pedraza-González (L)

Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro 2, I-53100 Siena, Italy.

María Del Carmen Marín (MDC)

Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro 2, I-53100 Siena, Italy.

Alejandro N Jorge (AN)

Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States of America.

Tyler D Ruck (TD)

Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States of America.

Xuchun Yang (X)

Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States of America.

Alessio Valentini (A)

Theoretical Physical Chemistry, Research Unit MolSys, Université de Liège, Allée du 6 Août, 11, 4000 Liège, Belgium.

Massimo Olivucci (M)

Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro 2, I-53100 Siena, Italy.
Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United States of America.

Luca De Vico (L)

Department of Biotechnology, Chemistry and Pharmacy, Università degli Studi di Siena, Via A. Moro 2, I-53100 Siena, Italy.

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