Effects of Lung Function-Related Genes and
Aged
Aged, 80 and over
Case-Control Studies
Cluster Analysis
Cytokines
/ genetics
Eosinophils
/ immunology
Female
Forced Expiratory Volume
Genetic Predisposition to Disease
Genotype
Humans
Leukocyte Count
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Pulmonary Disease, Chronic Obstructive
/ genetics
Risk Factors
Severity of Illness Index
Vital Capacity
COPD
TSLP
eosinophil
genetic risk score
lung function
Journal
COPD
ISSN: 1541-2563
Titre abrégé: COPD
Pays: England
ID NLM: 101211769
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
9
1
2020
medline:
6
7
2021
entrez:
9
1
2020
Statut:
ppublish
Résumé
A weighted genetic risk score (GRS) based on 16 SNPs implicated in reduced lung function in both Japanese and non-Japanese populations was previously associated with the onset of COPD and asthma. We here examine the genetic impact of this lung function GRS on specific COPD phenotypes. A cohort of Japanese COPD patients (
Identifiants
pubmed: 31910693
doi: 10.1080/15412555.2019.1708296
doi:
Substances chimiques
Cytokines
0
TSLP protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM