SOX9: The master regulator of cell fate in breast cancer.
Apoptosis
/ genetics
Breast Neoplasms
/ blood supply
Cell Proliferation
/ genetics
Disease Progression
Drug Resistance, Neoplasm
/ genetics
Epigenesis, Genetic
Female
Humans
MicroRNAs
/ genetics
Neoplastic Stem Cells
/ metabolism
Neovascularization, Pathologic
/ genetics
RNA Processing, Post-Transcriptional
RNA, Long Noncoding
/ genetics
SOX9 Transcription Factor
/ chemistry
Breast cancer
Chemoresistance
SOX9
Therapy
microRNA
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
06
11
2019
accepted:
24
12
2019
pubmed:
9
1
2020
medline:
25
8
2020
entrez:
9
1
2020
Statut:
ppublish
Résumé
SRY-related high-mobility group box 9 (SOX9) is an indispensable transcription factor that regulates multiple developmental pathways related to stemness, differentiation, and progenitor development. Previous studies have demonstrated that the SOX9 protein directs pathways involved in tumor initiation, proliferation, migration, chemoresistance, and stem cell maintenance, thereby regulating tumorigenesis as an oncogene. SOX9 overexpression is a frequent event in breast cancer (BC) subtypes. Of note, the molecular mechanisms and functional regulation underlying SOX9 upregulation during BC progression are still being uncovered. The focus of this review is to appraise recent advances regarding the involvement of SOX9 in BC pathogenesis. First, we provide a general overview of SOX9 structure and function, as well as its involvement in various kinds of cancer. Next, we discuss pathways of SOX9 regulation, particularly its miRNA-mediated regulation, in BC. Finally, we describe the involvement of SOX9 in BC pathogenesis via its regulation of pathways involved in regulating cancer hallmarks, as well as its clinical and therapeutic importance. In general, this review article aims to serve as an ample source of knowledge on the involvement of SOX9 in BC progression. Targeting SOX9 activity may improve therapeutic strategies to treat BC, but precisely inhibiting SOX9 using drugs and/or small peptides remains a huge challenge for forthcoming cancer research.
Identifiants
pubmed: 31911091
pii: S0006-2952(19)30488-5
doi: 10.1016/j.bcp.2019.113789
pmc: PMC9048250
mid: NIHMS1800043
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Long Noncoding
0
SOX9 Transcription Factor
0
SOX9 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
113789Subventions
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
BMC Cancer. 2017 Aug 2;17(1):515
pubmed: 28768501
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
PLoS One. 2014 Oct 07;9(10):e108942
pubmed: 25291178
Oncogene. 2004 Jun 3;23(26):4584-93
pubmed: 15077158
Dev Cell. 2012 Mar 13;22(3):597-609
pubmed: 22421045
Oncol Res Treat. 2017;40(1-2):15-20
pubmed: 28118628
Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1335-46
pubmed: 23064761
Hum Pathol. 2003 Mar;34(3):263-9
pubmed: 12673561
Breast Cancer Res Treat. 2015 Apr;150(3):685-95
pubmed: 25783182
Int J Clin Exp Pathol. 2015 Apr 01;8(4):3871-81
pubmed: 26097571
Nat Commun. 2016 Aug 24;7:12595
pubmed: 27553708
Nature. 1990 Jul 19;346(6281):240-4
pubmed: 1695712
Oncogene. 2014 May 15;33(20):2589-600
pubmed: 23752191
Oncotarget. 2017 Mar 14;8(11):17785-17794
pubmed: 28147312
Breast Cancer Res Treat. 2019 May;175(1):39-50
pubmed: 30712196
Stem Cells. 2013 Aug;31(8):1454-66
pubmed: 23592398
Stem Cells Int. 2017;2017:5091541
pubmed: 28392805
Int J Biochem Cell Biol. 2017 Jun;87:18-22
pubmed: 28323209
PLoS One. 2017 Nov 9;12(11):e0187814
pubmed: 29121666
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
Cell Rep. 2017 Mar 21;18(12):2825-2835
pubmed: 28329676
Cancer Res. 2008 Mar 15;68(6):1625-30
pubmed: 18339840
Genes Dev. 2003 Jul 1;17(13):1677-89
pubmed: 12842915
Oncogene. 2002 Nov 7;21(51):7850-60
pubmed: 12420222
Development. 2013 Oct;140(20):4129-44
pubmed: 24086078
Int J Clin Exp Med. 2015 Jun 15;8(6):9107-13
pubmed: 26309565
Int J Biochem Cell Biol. 2010 Mar;42(3):411-6
pubmed: 19808100
Pathol Int. 2009 Mar;59(3):121-36
pubmed: 19261089
Genomics. 1997 Jan 1;39(1):30-7
pubmed: 9027483
Mol Cancer Res. 2019 Jan;17(1):238-249
pubmed: 30206184
Cell. 2016 Mar 24;165(1):45-60
pubmed: 27015306
FEBS Open Bio. 2019 Nov;9(11):1957-1967
pubmed: 31538724
Cancer Res. 2019 Jul 15;79(14):3608-3621
pubmed: 31118200
RNA. 2020 Feb;26(2):175-185
pubmed: 31690584
Cancer Lett. 2007 Oct 8;255(2):182-93
pubmed: 17532558
Int J Oncol. 2018 Dec;53(6):2715-2726
pubmed: 30272349
Anticancer Res. 2015 Jan;35(1):207-19
pubmed: 25550553
Exp Biol Med (Maywood). 2011 Feb;236(2):145-55
pubmed: 21321311
Br J Cancer. 2019 Oct;121(8):679-689
pubmed: 31481734
Am J Pathol. 2012 Aug;181(2):684-92
pubmed: 22698986
PLoS One. 2008 Jul 16;3(7):e2714
pubmed: 18628953
Mol Cancer Res. 2014 Mar;12(3):421-32
pubmed: 24302456
Cancer Res. 2005 Mar 15;65(6):2193-8
pubmed: 15781631
Breast Cancer Res Treat. 2010 Apr;120(2):317-26
pubmed: 19322650
Genome Biol. 2015 Feb 22;16:42
pubmed: 25885555
Curr Biol. 2005 Aug 9;15(15):1340-51
pubmed: 16085486
Sci Rep. 2015 May 27;5:10398
pubmed: 26013289
Cancer Res. 2013 Apr 1;73(7):2159-69
pubmed: 23536563
PLoS One. 2014 Feb 03;9(2):e87878
pubmed: 24498388
Br J Cancer. 2008 Jan 29;98(2):466-73
pubmed: 18087279
Gene. 2018 Dec 30;679:138-149
pubmed: 30098428
Oncogene. 2019 Apr;38(17):3151-3169
pubmed: 30622340
J Clin Invest. 2009 Apr;119(4):954-63
pubmed: 19273910
J Neurooncol. 2006 Nov;80(2):151-5
pubmed: 16791471
Oncol Rep. 2013 Jan;29(1):125-32
pubmed: 23064448
Diagn Cytopathol. 2011 Feb;39(2):105-9
pubmed: 20301211
BMC Cancer. 2015 Oct 29;15:816
pubmed: 26510686
CA Cancer J Clin. 2019 Jan;69(1):7-34
pubmed: 30620402
Nucleic Acids Res. 2010 Oct;38(18):6018-28
pubmed: 20484372
Biochem Biophys Res Commun. 2017 Jan 1;482(1):126-133
pubmed: 27720715
Am J Clin Pathol. 2008 Dec;130(6):897-904
pubmed: 19019766
Cancer Cell. 2018 Mar 12;33(3):417-434.e7
pubmed: 29533783
Oncotarget. 2015 Aug 21;6(24):20711-22
pubmed: 26036262
Cancer Cell. 2007 Dec;12(6):559-71
pubmed: 18068632
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11199-204
pubmed: 12169669
Cell Biol Toxicol. 2014 Jun;30(3):157-67
pubmed: 24760606
Curr Opin Immunol. 2014 Apr;27:16-25
pubmed: 24531241
Horm Cancer. 2011 Apr;2(2):91-103
pubmed: 21761332
Int J Biochem Cell Biol. 2010 Mar;42(3):381-90
pubmed: 19631281
Oncol Res. 2017 Jan 26;25(2):167-176
pubmed: 28277188
Clin Chem Lab Med. 2012 Oct 1;50(10):1707-21
pubmed: 23089699
Oncol Rep. 2018 Nov;40(5):2487-2496
pubmed: 30132562
Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4429-34
pubmed: 17671126
Cancer Res. 2016 Nov 15;76(22):6735-6746
pubmed: 27569216
Cancer Microenviron. 2016 Apr;9(1):71-4
pubmed: 26412079
Cancers (Basel). 2019 Nov 16;11(11):
pubmed: 31744046
Genes Dis. 2014 Dec;1(2):149-161
pubmed: 25685828
RNA Biol. 2013 Aug;10(8):1283-90
pubmed: 23823647
FEBS Lett. 2012 Dec 14;586(24):4362-70
pubmed: 23178713
J Biol Chem. 2013 Mar 1;288(9):6478-87
pubmed: 23306204
Sci Rep. 2018 Jan 16;8(1):829
pubmed: 29339789
Development. 2003 Dec;130(23):5681-93
pubmed: 14522876
PLoS One. 2016 Dec 1;11(12):e0164845
pubmed: 27906963
Ann N Y Acad Sci. 2000 May;902:249-62; discussion 262-4
pubmed: 10865845
Genesis. 2005 Jan;41(1):23-32
pubmed: 15645446
Clin Cancer Res. 2017 Sep 1;23(17):5176-5186
pubmed: 28606919
Nat Rev Cancer. 2008 Oct;8(10):755-68
pubmed: 18784658
Clin Transl Oncol. 2008 Dec;10(12):786-93
pubmed: 19068449
J Biol Chem. 1997 Oct 31;272(44):27848-52
pubmed: 9346931
Virchows Arch. 2012 Mar;460(3):271-9
pubmed: 22331131
Mol Cell Biol. 1998 Nov;18(11):6653-65
pubmed: 9774680
Hum Mol Genet. 2011 Mar 15;20(6):1143-53
pubmed: 21212101
J Biol Chem. 2005 Aug 26;280(34):30517-25
pubmed: 15975921
Expert Rev Mol Diagn. 2018 Mar;18(3):227-243
pubmed: 29424261
PLoS One. 2018 Nov 12;13(11):e0207586
pubmed: 30419005
Springerplus. 2013 Dec 28;2:695
pubmed: 24404438
Nature. 1990 Jul 19;346(6281):245-50
pubmed: 2374589
Int J Cancer. 2002 Jul 10;100(2):144-51
pubmed: 12115562
Cell. 1994 Dec 16;79(6):1111-20
pubmed: 8001137
Oncotarget. 2016 Apr 12;7(15):19693-708
pubmed: 26930713
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1865-70
pubmed: 17267606
Dev Biol. 2007 May 1;305(1):120-32
pubmed: 17350610
Biochem Biophys Res Commun. 2016 Aug 26;477(3):461-6
pubmed: 27318091
Br J Cancer. 2018 Nov;119(11):1358-1366
pubmed: 30420613
Oncogene. 2019 Nov;38(47):7216-7233
pubmed: 31444414
Stem Cells Int. 2016;2016:2498764
pubmed: 26880941
Nat Commun. 2015 Jan 30;6:6170
pubmed: 25636082
J Exp Clin Cancer Res. 2019 Jan 18;38(1):22
pubmed: 30658681
Matrix Biol. 1998 Mar;16(9):529-40
pubmed: 9569122
Oncogene. 2011 Jun 2;30(22):2493-503
pubmed: 21297661
N Engl J Med. 2008 May 8;358(19):2039-49
pubmed: 18463380
J Exp Clin Cancer Res. 2017 Dec 13;36(1):182
pubmed: 29237490
J Cell Biochem. 2019 Jun;120(6):10767-10776
pubmed: 30672027
Cancer Metastasis Rev. 1992 Sep;11(2):121-39
pubmed: 1327566
Cell Biosci. 2019 Feb 07;9:16
pubmed: 30774927
Clin Cancer Res. 2010 Sep 1;16(17):4363-73
pubmed: 20651055
J Transl Med. 2018 Jul 2;16(1):180
pubmed: 29966523
Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4482-E4491
pubmed: 28507152
Cell Death Dis. 2018 Jul 3;9(7):752
pubmed: 29970901
Cancer Res. 2013 Jun 1;73(11):3425-40
pubmed: 23548270
J Comp Neurol. 2008 Sep 20;510(3):237-50
pubmed: 18626943
Cancer Res. 2010 Feb 1;70(3):979-87
pubmed: 20103652
Clin Transl Med. 2014 Jul 04;3:19
pubmed: 25114775
Cell. 2012 Mar 2;148(5):1015-28
pubmed: 22385965
J Cell Physiol. 2017 Aug;232(8):2112-2124
pubmed: 27748507
Development. 2009 Jan;136(1):129-38
pubmed: 19036799
Development. 2008 Feb;135(4):637-46
pubmed: 18184726
Hum Pathol. 2018 Jul;77:166-174
pubmed: 29634977
Cell. 2006 Nov 17;127(4):679-95
pubmed: 17110329
Breast Cancer Res Treat. 2015 Nov;154(1):45-55
pubmed: 26467042
Oncogene. 2016 Jun 2;35(22):2824-33
pubmed: 26387547
Oncogene. 2017 May 11;36(19):2737-2749
pubmed: 27991928
Cancer Cell. 2012 Dec 11;22(6):737-50
pubmed: 23201164