CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis.

Animals Biomarkers CARD Signaling Adaptor Proteins / genetics Cryptococcosis / immunology Cryptococcus neoformans / immunology Cytokines / metabolism Disease Models, Animal Disease Resistance / immunology Female Host-Pathogen Interactions / genetics Immunophenotyping Leukocytes / immunology Lung Diseases, Fungal / immunology Macrophage Activation / genetics Male Mice Receptors, Pattern Recognition / metabolism
CARD9 Cryptococcus neoformans cryptococcosis fungal immunology fungal pathogenesis host-pathogen interactions innate immunity macrophages medical mycology pattern recognition receptors

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
07 01 2020
Historique:
entrez: 9 1 2020
pubmed: 9 1 2020
medline: 26 9 2020
Statut: epublish

Résumé

Caspase recruitment domain-containing protein 9 (CARD9) is a critical adaptor molecule triggered by the interaction of C-type lectin receptors (CLRs) with carbohydrate motifs found in fungi. Consequently, clinical and animal studies indicate that CARD9 is an important regulator of protective immunity against fungal pathogens. Previous studies suggest that CARD9 is important for the induction of protection against

Identifiants

DOI: 10.1128/mBio.03005-19 PMID: 31911495 PMC: PMC6946806
pubmed: 31911495
pii: mBio.03005-19
doi: 10.1128/mBio.03005-19
pmc: PMC6946806
pii:
doi:

Substances chimiques

Biomarkers 0
CARD Signaling Adaptor Proteins 0
Card9 protein, mouse 0
Cytokines 0
Receptors, Pattern Recognition 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI071752
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI135005
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM060655
Pays : United States

Informations de copyright

Copyright © 2020 Campuzano et al.

Références

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Auteurs

Althea Campuzano (A)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.

Natalia Castro-Lopez (N)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.

Amanda J Martinez (AJ)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.

Michal A Olszewski (MA)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Michigan Medicine University, Ann Arbor, Michigan, USA.
VA Ann Arbor Healthcare System, Research Service, Ann Arbor, Michigan, USA.

Anutosh Ganguly (A)

VA Ann Arbor Healthcare System, Research Service, Ann Arbor, Michigan, USA.
Division of Hepatobiliary Surgery, Department of Surgery, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Chrissy Leopold Wager (C)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.

Chiung-Yu Hung (CY)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.

Floyd L Wormley (FL)

Department of Biology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA Floyd.Wormley@tcu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › Cryptococcose › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Cryptococcus › Cryptococcus neoformans › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Phénomènes physiologiques des plantes › Immunité des plantes › Résistance à la maladie › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Mycoses pulmonaires › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Phénomènes du système immunitaire › Cytotoxicité immunologique › Activation des macrophages › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › CARD9 Is Required for Classical Macrophage...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › CARD9 Is Required for Classical Macrophage...