Human papillomavirus (HPV) DNA detection in uterine cervix cancer after radiation indicating recurrence: a systematic review and meta-analysis.
Human Papillomavirus
Radiotherapy, Uterine Cervical Cancer
Recurrence
Journal
Journal of gynecologic oncology
ISSN: 2005-0399
Titre abrégé: J Gynecol Oncol
Pays: Korea (South)
ID NLM: 101483150
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
17
03
2019
revised:
20
05
2019
accepted:
05
09
2019
pubmed:
9
1
2020
medline:
23
4
2021
entrez:
9
1
2020
Statut:
ppublish
Résumé
The causal association of human papillomavirus (HPV) in uterine cervical cancer was well established and this oncogenic virus was reported to be a biomarker for overall recurrence and central pelvic recurrence. The objective of the present systematic review and meta-analysis was to assess the role of HPV DNA testing in early detection of recurrence among cervical cancer survivors after radiotherapy. We performed a systematic review and meta-analysis by means of searching electronic databases for published articles between January 1984 and June 2018, on the basis of standard systematic review guidelines prescribed by major agencies namely Cochrane Collaboration (https://www.cochrane.org) and Campbell Collaboration (https://www.campbellcollaboration.org). The meta-analysis component was further modified appropriately for the synthesis of sensitivity and specificity results. A total of 1,055 cervical cancer cases who had received pelvic radiation with or without chemotherapy from ten cohort studies were evaluated. The overall pooled sensitivity and specificity of HPV DNA testing was 0.84 (95% confidence interval [CI]= 0.66-0.94) and 0.35 (95% CI=0.20-0.54) respectively. The positive likelihood ratio was 1.3 (95% CI=1.0-1.7) and the negative likelihood ratio was 0.45 (95% CI=0.18-1.10) with an estimated diagnostic odds ratio of 3 (95% CI=1-9). The screening for HPV DNA testing during follow-up facilitates early detection of recurrence after radiotherapy.
Identifiants
pubmed: 31912676
pii: 31.e20
doi: 10.3802/jgo.2020.31.e20
pmc: PMC7044009
doi:
Substances chimiques
DNA, Viral
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e20Subventions
Organisme : Indian Council of Medical Research
ID : No.5/8/7/15/2010/ECD-I
Pays : India
Informations de copyright
Copyright © 2020. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
Références
Oncol Lett. 2018 Jan;15(1):459-466
pubmed: 29387229
N Engl J Med. 1996 Apr 18;334(16):1030-8
pubmed: 8598842
IARC Monogr Eval Carcinog Risks Hum. 1991;52:1-544
pubmed: 1683674
Int J Radiat Oncol Biol Phys. 2002 Apr 1;52(5):1345-51
pubmed: 11955748
Viruses. 2017 Sep 21;9(10):
pubmed: 28934151
Tumori. 2016 Oct 13;102(5):521-526
pubmed: 26350192
J Clin Oncol. 2007 Aug 20;25(24):3628-34
pubmed: 17704412
Int J Oncol. 2009 Jan;34(1):263-71
pubmed: 19082497
J Med Assoc Thai. 2012 May;95 Suppl 5:S38-41
pubmed: 22934443
J Pathol Clin Res. 2016 Jun 28;2(4):201-209
pubmed: 27917295
Arch Pathol Lab Med. 2015 Nov;139(11):1437-40
pubmed: 26516940
Am J Obstet Gynecol. 1972 Nov 15;114(6):755-64
pubmed: 4633572
Cancer Res. 2013 Aug 1;73(15):4791-800
pubmed: 23749640
Gynecol Oncol. 2013 May;129(2):406-11
pubmed: 23402906
J Med Virol. 2012 Jul;84(7):1115-9
pubmed: 22585730
Int J Gynecol Cancer. 2006 May-Jun;16(3):1048-54
pubmed: 16803484
J Clin Oncol. 2007 Jul 10;25(20):2952-65
pubmed: 17617527
N Engl J Med. 1999 Apr 15;340(15):1144-53
pubmed: 10202165
J Infect Dis. 1995 Nov;172(5):1184-90
pubmed: 7594652
Oncotarget. 2018 Apr 10;9(27):18786-18796
pubmed: 29721161
J Gynecol Oncol. 2015 Apr;26(2):111-7
pubmed: 25872892
Oncol Rep. 2010 Apr;23(4):1093-9
pubmed: 20204296
Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):609-14
pubmed: 21215531
Plast Reconstr Surg. 2010 Dec;126(6):2234-2242
pubmed: 20697313
Ecancermedicalscience. 2015 Apr 29;9:528
pubmed: 25987897
Gynecol Oncol. 2018 Feb;148(2):299-304
pubmed: 29203175
J Clin Oncol. 1998 Aug;16(8):2613-9
pubmed: 9704710
Am J Obstet Gynecol. 2004 Dec;191(6):1907-13
pubmed: 15592271
Indian J Med Paediatr Oncol. 2016 Oct-Dec;37(4):278-285
pubmed: 28144096
Int J Cancer. 2002 Nov 20;102(3):237-43
pubmed: 12397642
Int J Cancer. 2011 Aug 15;129(4):896-902
pubmed: 21064095
Oncotarget. 2017 Jun 16;8(39):66352-66359
pubmed: 29029517
Gynecol Oncol Rep. 2017 Sep 01;22:16-20
pubmed: 28948205
J Gynecol Oncol. 2011 Mar 31;22(1):32-8
pubmed: 21607093
Gynecol Oncol. 1991 May;41(2):123-8
pubmed: 1646755