Intermittent low dose carbon monoxide inhalation does not influence glucose regulation in overweight adults: a randomized controlled crossover trial.
Adult
Blood Glucose
/ drug effects
Body Mass Index
Carbon Monoxide
/ administration & dosage
Cross-Over Studies
Fasting
/ metabolism
Female
Glucose
/ metabolism
Glucose Tolerance Test
/ methods
Humans
Insulin
/ metabolism
Insulin Resistance
/ physiology
Male
Overweight
/ drug therapy
Single-Blind Method
Young Adult
carboxyhaemoglobin
gasotransmitters
glucose metabolism
insulin
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
14
11
2019
accepted:
03
01
2020
pubmed:
9
1
2020
medline:
20
8
2021
entrez:
9
1
2020
Statut:
ppublish
Résumé
What is the central question of this study? Low dose carbon monoxide (CO) inhalation plays a role in regulating proteins involved in glucose metabolism; does low dose CO improve glucose and insulin responses to an oral glucose tolerance test in overweight adults? What is the main finding and its importance? Five days of intermittent CO inhalation does not alter the glucose or insulin responses to ingestion of a glucose bolus in overweight adults. Low dose CO is utilized in various physiological assessment procedures; these findings allow researchers and clinicians to utilize these procedures without concern of altering glucose metabolism. Low dose carbon monoxide (CO) inhalation upregulates several proteins important for glucose metabolism. Such changes could be clinically significant and may be relevant to those who use CO as a research tool. We hypothesized that low dose CO inhalation would improve glucose and insulin responses to an oral glucose bolus in overweight humans. Eleven young adults (5 men, 6 women; body mass index: 25-35 kg m
Substances chimiques
Blood Glucose
0
Insulin
0
Carbon Monoxide
7U1EE4V452
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
460-467Subventions
Organisme : University of Colorado Boulder
Pays : International
Organisme : Colorado State University
Pays : International
Organisme : NCRR NIH HHS
ID : UL1 RR025780
Pays : United States
Informations de copyright
© 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.
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