Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Animals
Antigens, CD
/ metabolism
Biomarkers
/ metabolism
Bone Marrow Cells
/ drug effects
Bone Morphogenetic Protein Receptors, Type I
/ metabolism
Cell Count
Cells, Cultured
Chemokine CXCL12
/ pharmacology
Gene Expression Regulation
/ drug effects
Glucosephosphate Dehydrogenase
/ antagonists & inhibitors
Green Fluorescent Proteins
/ metabolism
Heart
/ physiopathology
Hematopoietic Stem Cells
/ drug effects
Hypertension, Pulmonary
/ etiology
Hypoxia
/ blood
Lung
/ pathology
Mice, Inbred C57BL
Mice, Transgenic
Pluripotent Stem Cells
/ drug effects
Pulmonary Artery
/ drug effects
Receptors, Adrenergic, alpha
/ metabolism
Wnt Signaling Pathway
/ genetics
human PAH
hypoxia
lung
pulmonary hypertension
stem cells
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
9
1
2020
medline:
13
5
2020
entrez:
9
1
2020
Statut:
ppublish
Résumé
Pulmonary hypertension (PH) is a multicellular and progressive disease with a high mortality rate. Among many cell types, hematopoietic stem cells (HSCs) are incriminated in the pathogenesis of PH. However, our understanding of the mechanisms that increase HSCs in blood and lungs of hypertensive animals or patients and the role played by HSCs in the pathogenesis of PH remains elusive. Studies suggest that glycolysis is critical for the survival and growth of HSCs. In various cell types from hypertensive lungs of animals and patients, glycolysis and the glucose-6-phosphate dehydrogenase (G6PD) activity are increased. Herein, we demonstrated in mice that chronic hypoxia increased HSCs (CD34
Identifiants
pubmed: 31913656
doi: 10.1152/ajplung.00327.2019
pmc: PMC7052680
doi:
Substances chimiques
Antigens, CD
0
Biomarkers
0
Chemokine CXCL12
0
Receptors, Adrenergic, alpha
0
Green Fluorescent Proteins
147336-22-9
Glucosephosphate Dehydrogenase
EC 1.1.1.49
Bone Morphogenetic Protein Receptors, Type I
EC 2.7.11.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L386-L401Subventions
Organisme : Cancer Research UK
ID : C480/A1141
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL129797
Pays : United States
Organisme : Cancer Research UK
ID : C5759/A17098
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL151187
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132574
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115124
Pays : United States
Références
Hypertension. 2016 Nov;68(5):1255-1263
pubmed: 27672025
Cancer Res. 2009 Sep 15;69(18):7243-51
pubmed: 19738068
Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L287-300
pubmed: 25480333
Curr Protoc Mouse Biol. 2011 Mar 1;1:71-83
pubmed: 21743841
Pulm Circ. 2012 Jan-Mar;2(1):54-60
pubmed: 22558520
J Med Chem. 2012 May 10;55(9):4431-45
pubmed: 22506561
Cardiovasc Res. 2016 Jul 1;111(1):16-25
pubmed: 27037259
J Clin Invest. 2012 Aug;122(8):2749-55
pubmed: 22850885
Ann Am Thorac Soc. 2013 Feb;10(1):1-9
pubmed: 23509326
Cell. 2012 Jul 20;150(2):351-65
pubmed: 22817897
Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L744-55
pubmed: 18723761
Circulation. 2010 Jun 29;121(25):2747-54
pubmed: 20547927
Circ Res. 2018 Dec 7;123(12):e51-e64
pubmed: 30566041
Blood. 2005 Mar 1;105(5):1905-15
pubmed: 15498852
Blood. 2012 Aug 9;120(6):1218-27
pubmed: 22745307
Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H689-98
pubmed: 27422986
Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H293-H303
pubmed: 28550179
Mol Reprod Dev. 2015 Jul-Aug;82(7-8):518-29
pubmed: 26153368
Circulation. 2002 Apr 9;105(14):1672-8
pubmed: 11940546
Circ Cardiovasc Imaging. 2010 Mar;3(2):157-63
pubmed: 20044514
Nature. 2003 May 22;423(6938):448-52
pubmed: 12717451
Am J Physiol Lung Cell Mol Physiol. 2008 Dec;295(6):L1028-39
pubmed: 18931051
Cell Stem Cell. 2014 Aug 7;15(2):169-84
pubmed: 24953180
Arthritis Rheum. 2004 Apr;50(4):1296-304
pubmed: 15077314
Exp Hematol. 2000 Aug;28(8):875-84
pubmed: 10989188
Eur Respir J. 2016 Aug;48(2):459-69
pubmed: 27103380
Eur Respir J. 2010 Dec;36(6):1284-93
pubmed: 20413531
Circulation. 2009 Jan 27;119(3):374-81
pubmed: 19139384
Blood. 2011 Mar 31;117(13):3485-93
pubmed: 21258008
Nature. 2003 Oct 23;425(6960):836-41
pubmed: 14574412
Am J Respir Crit Care Med. 2011 Jul 1;184(1):116-23
pubmed: 21471108
J Physiol Sci. 2009 Nov;59(6):429-37
pubmed: 19636669
Am J Pathol. 2008 Mar;172(3):615-27
pubmed: 18258847
PLoS One. 2014 Aug 29;9(8):e106163
pubmed: 25171153
Blood. 2000 May 15;95(10):3106-12
pubmed: 10807776
Circulation. 2016 Oct 11;134(15):1105-1121
pubmed: 27562971
Nature. 1997 Oct 30;389(6654):990-4
pubmed: 9353125
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5582-7
pubmed: 23509298
Stem Cells. 1998;16(6):387-96
pubmed: 9831864
Pulm Circ. 2013 Apr;3(2):294-314
pubmed: 24015330
Nature. 2003 May 22;423(6938):409-14
pubmed: 12717450
Cancer Res. 2007 May 1;67(9):4010-5
pubmed: 17483311
Cardiovasc Res. 2018 Mar 15;114(4):551-564
pubmed: 29385432
Am J Respir Crit Care Med. 2011 Nov 15;184(10):1171-82
pubmed: 21868504
Oncogene. 2005 Aug 29;24(37):5676-92
pubmed: 16123801
Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L870-8
pubmed: 19286928
J Pharmacol Exp Ther. 2010 Feb;332(2):455-62
pubmed: 19915069
Blood. 1997 Dec 15;90(12):5002-12
pubmed: 9389720
Antioxid Redox Signal. 2018 Jan 20;28(3):230-250
pubmed: 28637353
Immunity. 2008 Jan;28(1):1-4
pubmed: 18199409
Pulm Circ. 2016 Sep;6(3):360-8
pubmed: 27683613
Cell Stem Cell. 2007 Sep 13;1(3):313-23
pubmed: 18371365
FASEB J. 2015 Jan;29(1):105-15
pubmed: 25342128
Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H214-24
pubmed: 24213617
J Immunol. 2014 Jul 15;193(2):597-609
pubmed: 24928992
N Engl J Med. 2003 Feb 6;348(6):500-9
pubmed: 12571257
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L545-56
pubmed: 25063801
Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H904-H912
pubmed: 27521420
Recent Prog Horm Res. 2003;58:283-95
pubmed: 12795424
Int J Cardiol. 2017 Feb 1;228:238-243
pubmed: 27865192
Exp Lung Res. 2008 Aug;34(6):313-23
pubmed: 18600498
Circulation. 2004 Sep 14;110(11):1499-506
pubmed: 15353500
J Clin Invest. 2016 Sep 1;126(9):3511-25
pubmed: 27548529
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1013-32
pubmed: 19748998
J Clin Invest. 2008 Jun;118(6):2111-20
pubmed: 18497886
Clin Exp Rheumatol. 2008 May-Jun;26(3):421-9
pubmed: 18578963
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Cell Stem Cell. 2015 Dec 3;17(6):651-662
pubmed: 26637942
Am J Respir Crit Care Med. 2009 Oct 15;180(8):780-7
pubmed: 19628780
J Clin Invest. 2004 Jul;114(2):182-95
pubmed: 15254585
Arthritis Rheumatol. 2015 Feb;67(2):498-507
pubmed: 25385504
Am J Respir Crit Care Med. 2016 Apr 15;193(8):898-909
pubmed: 26651104
Biol Chem. 2008 Jul;389(7):813-24
pubmed: 18627318