The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity.
Amino Acid Sequence
Base Sequence
Binding Sites
Crystallography, X-Ray
DNA
/ chemistry
DNA Methylation
Electrophoretic Mobility Shift Assay
Forkhead Transcription Factors
/ chemistry
Humans
Protein Binding
Protein Conformation, alpha-Helical
Protein Structure, Tertiary
Recombinant Proteins
/ biosynthesis
Sequence Alignment
DNA–protein interaction
crystal structure
forkhead box N1
gene regulation
immunodeficiency
thymus
transcription factor
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
06 03 2020
06 03 2020
Historique:
received:
25
07
2019
revised:
23
12
2019
pubmed:
9
1
2020
medline:
21
10
2020
entrez:
9
1
2020
Statut:
ppublish
Résumé
Forkhead box N1 (FOXN1) is a member of the forkhead box family of transcription factors and plays an important role in thymic epithelial cell differentiation and development.
Identifiants
pubmed: 31914405
pii: S0021-9258(17)49502-0
doi: 10.1074/jbc.RA119.010365
pmc: PMC7062188
pii:
doi:
Substances chimiques
Forkhead Transcription Factors
0
Recombinant Proteins
0
Whn protein
0
DNA
9007-49-2
Banques de données
PDB
['5OCN', '6EL8']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2948-2958Subventions
Organisme : Wellcome Trust
ID : 211944/Z/18/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106169/ZZ14/Z
Pays : United Kingdom
Informations de copyright
© 2020 Newman et al.
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