Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling.
clinical
inflammation
mRNA
tendinopathy
ultrasound
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
25
05
2019
revised:
09
09
2019
accepted:
23
10
2019
entrez:
10
1
2020
pubmed:
10
1
2020
medline:
8
7
2020
Statut:
ppublish
Résumé
Overloading of tendon tissue with resulting chronic pain (tendinopathy) is a common disorder in occupational-, leisure- and sports-activity, but its pathogenesis remains poorly understood. To investigate the very early phase of tendinopathy, Achilles and patellar tendons were investigated in 200 physically active patients and 50 healthy control persons. Patients were divided into three groups: symptoms for 0-1 months (T1), 1-2 months (T2) or 2-3 months (T3). Tendinopathic Achilles tendon cross-sectional area determined by ultrasonography (US) was ~25% larger than in healthy control persons. Both Achilles and patellar anterior-posterior diameter were elevated in tendinopathy, and only later in Achilles was the width increased. Increased tendon size was accompanied by an increase in hypervascularization (US Doppler flow) without any change in mRNA for angiogenic factors. From patellar biopsies taken bilaterally, mRNA for most growth factors and tendon components remained unchanged (except for TGF-beta1 and substance-P) in early tendinopathy. Tendon stiffness remained unaltered over the first three months of tendinopathy and was similar to the asymptomatic contra-lateral tendon. In conclusion, this suggests that tendinopathy pathogenesis represents a disturbed tissue homeostasis with fluid accumulation. The disturbance is likely induced by repeated mechanical overloading rather than a partial rupture of the tendon.
Identifiants
pubmed: 31914656
doi: 10.1096/fj.201901309R
doi:
Banques de données
GENBANK
['NM_053275.3', 'NM_002046.4', 'NM_000088.3', 'NM_000090.3', 'NM_002160.3', 'NM_001920.5', 'NM_212482.3', 'NM_022144.3', 'NM_004530.5', 'NM_002422.4', 'NM_000660.6', 'NM_003238.4', 'NM_003239.4', 'NM_000618.3', 'NM_001901.3', 'NM_002211.4', 'NM_001964.3', 'NM_006206.6', 'NM_013996.2', 'NM_005345.5', 'NM_001674.4', 'NM_001675.4', 'NM_000962.3', 'NM_000959.4', 'NM_001025366.2', 'NM_139314.3', 'NM_004707.4', 'NM_003766.4', 'NM_022818.5', 'NM_000518.5']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
776-788Informations de copyright
© 2019 Federation of American Societies for Experimental Biology.
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