Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
05
08
2019
accepted:
01
01
2020
pubmed:
10
1
2020
medline:
4
8
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
Sodium-glucose cotransport 2 inhibitors (SGLT2i) lower plasma glucose but stimulate endogenous glucose production (EGP). The current study examined the effect of dapagliflozin on EGP while clamping plasma glucose, insulin, and glucagon concentrations at their fasting level. Thirty-eight patients with type 2 diabetes received an 8-h measurement of EGP ([3-
Identifiants
pubmed: 31915153
pii: db19-0770
doi: 10.2337/db19-0770
pmc: PMC7085246
doi:
Substances chimiques
Benzhydryl Compounds
0
Blood Glucose
0
Glucosides
0
Insulin
0
Sodium-Glucose Transporter 2 Inhibitors
0
dapagliflozin
1ULL0QJ8UC
Glucagon
9007-92-5
Banques de données
ClinicalTrials.gov
['NCT02592421']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
681-688Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK107680
Pays : United States
Informations de copyright
© 2020 by the American Diabetes Association.
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