Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections.
Streptococcus pyogenes
intravenous immunoglobulin G
necrotizing fasciitis
necrotizing soft tissue infections
superantigens
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
23 10 2020
23 10 2020
Historique:
received:
11
09
2019
accepted:
08
01
2020
pubmed:
10
1
2020
medline:
28
4
2021
entrez:
10
1
2020
Statut:
ppublish
Résumé
Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.
Identifiants
pubmed: 31916575
pii: 5698680
doi: 10.1093/cid/ciaa022
doi:
Substances chimiques
Immunoglobulins, Intravenous
0
Superantigens
0
Banques de données
ClinicalTrials.gov
['NCT02111161', 'NCT01790698']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1772-1775Investigateurs
Michael Nekludov
(M)
Anders Kjellberg
(A)
Trond Bruun
(T)
Torbjørn Nedrebø
(T)
Dag Harald Skutlaberg
(DH)
Anshu Babbar
(A)
Anders Rosà N
(A)
Vitor A P Martins Dos Santos
(VAP)
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.