Plasmacytoid dendritic cells from parent strains of the NZB/W F1 lupus mouse contribute different characteristics to autoimmune propensity.
Animals
Autoimmunity
B-Lymphocytes
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
CD8 Antigens
/ immunology
Cell Survival
/ immunology
Dendritic Cells
/ cytology
Forkhead Transcription Factors
/ metabolism
Interferon-alpha
/ metabolism
Interferons
/ metabolism
Lupus Erythematosus, Systemic
/ immunology
Lymphocyte Activation
/ immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred NZB
Mice, Knockout
Mice, Transgenic
Oligodeoxyribonucleotides
/ pharmacology
Apoptosis
interferon
lupus
plasmacytoid dendritic cells
Journal
Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
19
07
2019
revised:
06
01
2020
accepted:
07
01
2020
pubmed:
10
1
2020
medline:
18
11
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
The NZB/W F1 (F1) mice develop severe disease that is similar to human systemic lupus erythematosus. By contrast, each parent strain, NZB or NZW, has limited autoimmunity, suggesting traits of both strains contribute to pathogenesis. Although many of the contributing genes have been identified, the contributing cellular abnormality associated with each parent strain remains unresolved. Given that plasmacytoid dendritic cells (pDCs) are key to the pathogenesis of lupus, we investigated the properties of pDCs from NZB and NZW mice. We found that NZB mouse had higher numbers of pDCs, with much of the increase being contributed by a more abundant CD8
Substances chimiques
CD8 Antigens
0
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Ifnl3 protein, mouse
0
Interferon-alpha
0
Oligodeoxyribonucleotides
0
Interferons
9008-11-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
203-214Informations de copyright
© 2020 Australian and New Zealand Society for Immunology Inc.
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