Salivary microbiota and inflammation-related proteins in patients with psoriasis.
inflammation
microbiota
periodontitis
psoriasis
saliva
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
25
11
2019
revised:
13
12
2019
accepted:
05
01
2020
pubmed:
10
1
2020
medline:
31
7
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation-related proteins (neutrophil gelatinase-associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively. Stimulated saliva samples from patients with psoriasis (n = 27), patients with periodontitis (n = 58), and orally healthy controls (n = 52) were characterized by means of next-generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays. Linear discriminant effect size analysis showed that 52 (22 psoriasis-associated and 30 periodontitis-associated) and 21 (8 psoriasis-associated and 13 orally healthy control-associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p < .0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p < .0001) were identified in patients with psoriasis. Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation-related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.
Identifiants
pubmed: 31916654
doi: 10.1111/odi.13277
pmc: PMC7188313
doi:
Substances chimiques
LCN2 protein, human
0
Lipocalin-2
0
RNA, Ribosomal, 16S
0
Transferrin
0
Types de publication
Journal Article
Langues
eng
Pagination
677-687Subventions
Organisme : the Danish Foundation for Mutual Efforts in Dental Care
Organisme : Independent Research Council Denmark
Organisme : the Danish Dental Association
Informations de copyright
© 2020 The Authors. Oral Diseases published by John Wiley & Sons Ltd. All rights reserved.
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