Interaction between DNA damage response and autophagy in colorectal cancer.
Autophagy
Colorectal cancer
DNA damage
DNA repair
Journal
Gene
ISSN: 1879-0038
Titre abrégé: Gene
Pays: Netherlands
ID NLM: 7706761
Informations de publication
Date de publication:
10 Mar 2020
10 Mar 2020
Historique:
received:
23
08
2019
revised:
21
12
2019
accepted:
30
12
2019
pubmed:
10
1
2020
medline:
10
3
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
The subjection of DNA to numerous lethal damages is threatening for the stability and integrity of the whole body genome. DNA damage response (DDR) is a critical phosphorylation-based signaling pathway developed for the maintaining of the genome against these threatens. Recent studies showed that various targets of DDR are involved in the activation of autophagy, as one of the important effectors of this signaling. The interplay between DDR and autophagy may have a critical role in the pathogenesis of various malignancies such as colorectal cancer, which can be a basement for the designing novel therapeutic strategies for combating this cancer type. On the other hand, autophagy is also demonstrated to be contributed to the regulation of DDR components. Therefore, in this review article, we will discuss the crosstalk between DDR and autophagy and their exact function in the pathogenesis of various human cancer types, with special attention on colorectal cancer.
Identifiants
pubmed: 31917230
pii: S0378-1119(19)30982-5
doi: 10.1016/j.gene.2019.144323
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
144323Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.