Conjugated Linoleic Acid and Alpha Linolenic Acid Improve Cholesterol Homeostasis in Obesity by Modulating Distinct Hepatic Protein Pathways.
ATP Binding Cassette Transporter, Subfamily G, Member 5
/ metabolism
ATP Binding Cassette Transporter, Subfamily G, Member 8
/ metabolism
Animals
Apolipoprotein E3
/ genetics
Cholesterol
/ metabolism
Diet, High-Fat
/ adverse effects
Dietary Supplements
Feces
Linoleic Acids, Conjugated
/ pharmacology
Lipoproteins
/ metabolism
Liver
/ drug effects
Macrophages
/ drug effects
Male
Mice, Transgenic
Obesity
/ diet therapy
Sterol Regulatory Element Binding Protein 2
/ metabolism
alpha-Linolenic Acid
/ pharmacology
liver proteome
obesity and cholesterol
polyunsaturated fatty acids
reverse cholesterol transport
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
31
05
2019
revised:
11
11
2019
pubmed:
10
1
2020
medline:
16
6
2021
entrez:
10
1
2020
Statut:
ppublish
Résumé
High-fat diet (HFD)-induced obesity impairs macrophage-to-feces reverse cholesterol transport (RCT). It is hypothesized that dietary supplementation with the polyunsaturated fatty acids conjugated linoleic acid (CLA) or alpha linolenic acid (ALA) would prevent HFD-impaired RCT by modulating hepatic protein pathways. ApoE3L.CETP mice are fed a HFD supplemented ± CLA or ALA for 12 weeks and in vivo macrophage-to-feces RCT is determined. Hepatic cholesterol transporters and the hepatic proteome are assessed by immunoblotting and mass spectrometry, respectively. Mice fed HFD alone, but not ALA-HFD or CLA-HFD, exhibit increased systemic cholesterol levels, increased ALA and CLA exert distinct mechanistic advantages on cholesterol homeostasis and RCT in obesity.
Identifiants
pubmed: 31917888
doi: 10.1002/mnfr.201900599
doi:
Substances chimiques
ABCG5 protein, mouse
0
ATP Binding Cassette Transporter, Subfamily G, Member 5
0
ATP Binding Cassette Transporter, Subfamily G, Member 8
0
Abcg8 protein, rat
0
Apolipoprotein E3
0
Linoleic Acids, Conjugated
0
Lipoproteins
0
Srebf2 protein, mouse
0
Sterol Regulatory Element Binding Protein 2
0
apolipoprotein E3 (Leidein)
0
alpha-Linolenic Acid
0RBV727H71
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900599Subventions
Organisme : Wellcome Trust
ID : 097311/Z/11/Z
Pays : United Kingdom
Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
D. J. Rader, Am. J. Med. 2007, 120, S12.
D. J. Rader, Am. J. Cardiol. 2003, 92, 42J.
M. O'Reilly, E. Dillon, W. Guo, O. Finucane, A. McMorrow, A. Murphy, C. Lyons, D. Jones, M. Ryan, M. Gibney, E. Gibney, L. Brennan, M. de la Llera Moya, M. P. Reilly, H. M. Roche, F. C. McGillicuddy, Circulation 2016, 133, 1838.
S. S. Back, J. Kim, D. Choi, E. S. Lee, S. Y. Choi, K. Han, BMB Rep. 2013, 46, 322.
J. Noe, G. A. Kullak-Ublick, W. Jochum, B. Stieger, R. Kerb, M. Haberl, B. Müllhaupt, P. J. Meier, C. Pauli-Magnus, J. Hepatol. 2005, 43, 536.
F. Kasbi Chadli, H. Nazih, M. Krempf, P. Nguyen, K. Ouguerram, PLoS One 2013, 8, e61109.
T. Nishimoto, M. A. Pellizzon, M. Aihara, I. M. Stylianou, J. T. Billheimer, G. Rothblat, D. J. Rader, Arterioscler. Thromb. Vasc. Biol. 2009, 29, 1502.
J. C. Escola-Gil, G. Llaverias, J. Julve, M. Jauhiainen, J. Méndez-González, F. Blanco-Vaca, Arterioscler. Thromb. Vasc. Biol. 2011, 31, 2493.
A. P. Simopoulos, Exp. Biol. Med. 2008, 233, 674.
C. N. Serhan, S. Hong, K. Gronert, S. P. Colgan, P. R. Devchand, G. Mirick, R. L. Moussignac, J. Exp. Med. 2002, 196, 1025.
C. N. Serhan, N. Chiang, Br. J. Pharmacol. 2008, 153, S200.
M. de Lorgeril, S. Renaud, N. Mamelle, P. Salen, J. L. Martin, I. Monjaud, J. Guidollet, P. Touboul, J. Delaye, Lancet 1994, 343, 1454.
H. Han, P. Yan, L. Chen, C. Luo, H. Gao, Q. Deng, M. Zheng, Y. Shi, L. Liu, Oxid. Med. Cell Longev. 2015, 2015, 958217.
Y. L. Ha, N. K. Grimm, M. W. Pariza, Carcinogenesis 1987, 8, 1881.
S. Banni, Curr. Opin. Lipidol. 2002, 13, 261.
J. M. Griinari, D. A. Dwyer, M. A. McGuire, D. E. Bauman, D. L. Palmquist, K. V. Nurmela, J. Dairy Sci. 1998, 81, 1251.
P. W. Parodi, J. Dairy Sci. 1999, 82, 1339.
M. de Gaetano, K. Alghamdi, S. Marcone, O. Belton, J. Inflammation 2015, 12, 15.
S. Toomey, B. Harhen, H. M. Roche, D. Fitzgerald, O. Belton, Atherosclerosis 2006, 187, 40.
A. M. van den Maagdenberg, M. H. Hofker, P. J. Krimpenfort, I. de Bruijn, B. van Vlijmen, H. van der Boom, L. M. Havekes, R. R. Frants, J. Biol. Chem. 1993, 268, 10540.
M. O'Reilly, E. Dillon, W. Guo, O. Finucane, A. McMorrow, A. Murphy, C. Lyons, D. Jones, M. Ryan, M. Gibney, E. Gibney, L. Brennan, M. de la Llera Moya, M. P. Reilly, H. M. Roche, F. C. McGillicuddy, Circulation 2016, 133, 1838.
A. Rohlmann, M. Gotthardt, R. E. Hammer, J. Herz, J. Clin. Invest. 1998, 101, 689.
L. Cedo, J. Metso, D. Santos, J. L. Sanchez-Quesada, J. Julve, A. García-León, J. Mora-Brugués, M. Jauhiainen, F. Blanco-Vaca, J. C. Escolà-Gil, Mol. Nutr. Food Res. 2015, 59, 1987.
V. Buonacorso, E. R. Nakandakare, V. S. Nunes, M. Passarelli, E. C. Quintão, A. M. Lottenberg, Am. J. Clin. Nutr. 2007, 86, 1270.
I. K. Lesna, P. Suchanek, J. Kovar, P. Stavek, R. Poledne, J. Lipid Res. 2008, 49, 2414.
D. Mozaffarian, R. Micha, S. Wallace, PLoS Med. 2010, 7, e1000252.
F. B. Hu, W. C. Willett, JAMA 2002, 288, 2569.
Scientific Advisory Committee on Nutrition, Saturated Fats and Health Report, Public Health England, 2019, https://www.gov.uk/government/publications/saturated-fats-and-health-sacn-report.
P. M. Miotto, M. Horbatuk, R. Proudfoot, S. Matravadia, M. Bakovic, A. Chabowski, G. P. Holloway, Am. J. Physiol. 2017, 312, E461.
T. Murase, M. Aoki, I. Tokimitsu, Bioch. Biophys. Acta 2005, 1733, 224.
W. Wahli, P. R. Devchand, A. I. Jpenberg, B. Desvergne, Adv. Exp. Med. Biol. 1999, 447, 199.
B. M. Forman, J. Chen, R. M. Evans, Proc. Natl. Acad. Sci. U. S. A. 1997, 94, 4312.
W. H. Kunau, V. Dommes, H. Schulz, Prog. Lipid Res. 1995, 34, 267.
J. Huang, N. Viswakarma, S. Yu, Y. Jia, L. Bai, A. Vluggens, M. Cherkaoui-Malki, M. Khan, I. Singh, G. Yang, M. S. Rao, J. Borensztajn, J. K. Reddy, Am. J. Pathol. 2011, 179, 703.
T. Ide, M. Murata, M. Sugano, J. Lipid Res. 1996, 37, 448.
N. Willumsen, H. Vaagenes, O. Lie, A. C. Rustan, R. K. Berge, Lipids 1996, 31, 579.
X. C. Jiang, L. B. Agellon, A. Walsh, J. L. Breslow, A. Tall, J. Clin. Invest. 1992, 90, 1290.
M. Westerterp, C. C. van der Hoogt, W. de Haan, E. H. Offerman, G. M. Dallinga-Thie, J. W. Jukema, L. M. Havekes, P. C. Rensen, Arterioscler. Thromb. Vasc. Biol. 2006, 26, 2552.
J. Vikari, Scand J. Clin. Lab Invest. 1976, 36, 265.
X. Wang, H. L. Collins, M. Ranalletta, I. V. Fuki, J. T. Billheimer, G. H. Rothblat, A. R. Tall, D. J. Rader, J. Clin. Invest. 2007, 117, 2216.
F. C. McGillicuddy, M. de la Llera Moya, C. C. Hinkle, M. R. Joshi, E. H. Chiquoine, J. T. Billheimer, G. H. Rothblat, M. P. Reilly, Circulation 2009, 119, 1135.
A. Kramer, J. Green, J. Pollard Jr., S. Tugendreich, Bioinformatics 2014, 30, 523.