BRAHMA: Population specific T1, T2, and FLAIR weighted brain templates and their impact in structural and functional imaging studies.
Adult
Algorithms
Asian People
Brain
/ diagnostic imaging
Brain Mapping
Contrast Media
Female
Humans
Image Processing, Computer-Assisted
/ methods
Imaging, Three-Dimensional
India
/ epidemiology
Magnetic Resonance Imaging
Male
Memory, Short-Term
Probability
Software
Substantia Nigra
/ diagnostic imaging
Young Adult
Brain atlases
Brain templates
MRI
Registration
Template construction toolbox
Tissue probability maps
Journal
Magnetic resonance imaging
ISSN: 1873-5894
Titre abrégé: Magn Reson Imaging
Pays: Netherlands
ID NLM: 8214883
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
29
08
2019
revised:
18
11
2019
accepted:
30
12
2019
pubmed:
10
1
2020
medline:
1
12
2020
entrez:
10
1
2020
Statut:
ppublish
Résumé
Differences in brain morphology across population groups necessitate creation of population-specific Magnetic Resonance Imaging (MRI) brain templates for interpretation of neuroimaging data. Variations in the neuroanatomy in a genetically heterogeneous population make the development of a population-specific brain template for the Indian subcontinent imperative. A dataset of high-resolution 3D T1, T2-weighted, and FLAIR images acquired from a group of 113 volunteers (M/F - 56/57, mean age-28.96 ± 7.80 years) are used to construct T1, T2-weighted, and FLAIR templates, collectively referred to as Indian Brain Template, "BRAHMA". A processing pipeline is developed and implemented in a MATLAB based toolbox for template construction and generation of tissue probability maps and segmentation atlases, with additional labels for deep brain regions such as the Substantia Nigra generated from the T2-weighted and FLAIR templates. The use of BRAHMA template for analysis of structural and functional neuroimaging data obtained from Indian participants, provides improved accuracy with statistically significant results over that obtained using the ICBM-152 (International Consortium for Brain Mapping) template. Our results indicate that segmentations generated on structural images are closer in volume to those obtained from registration to the BRAHMA template than to the ICBM-152. Furthermore, functional MRI data obtained for Working Memory and Finger Tapping paradigms processed using the BRAHMA template show a significantly higher percentage of the activation area than ICBM-152 in relevant brain regions, i.e. the left middle frontal gyrus, and the left and right precentral gyri, respectively. The availability of different image contrasts, tissue maps, and segmentation atlases makes the BRAHMA template a comprehensive tool for multi-modal image analysis in laboratory and clinical settings.
Identifiants
pubmed: 31917995
pii: S0730-725X(19)30524-7
doi: 10.1016/j.mri.2019.12.009
pii:
doi:
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5-21Informations de copyright
Copyright © 2019. Published by Elsevier Inc.