Amyloid PET findings in multiple sclerosis are associated with cognitive decline at 18 months.
Cognitive impairment
Florbetaben
Multiple sclerosis
Myelin
Positron emission tomography
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
02 Jan 2020
02 Jan 2020
Historique:
received:
13
11
2019
revised:
16
12
2019
accepted:
01
01
2020
pubmed:
10
1
2020
medline:
10
1
2020
entrez:
10
1
2020
Statut:
aheadofprint
Résumé
To study the clinical, cognitive, and radiological progression of a cohort of patients with MS, taking into account the amyloid PET with Twenty-nine patients with MS were assessed with longitudinal structural MRI and a clinical and comprehensive neuropsychological protocol, with a mean interval between assessments of 18 ± 3.31 months. Patients with cognitive decline over the follow-up period showed a lower standardised uptake value ratio in NAWM and lower thalamic volume and a higher lesion load in the baseline MRI. Myelin status was correlated with EDSS and cognitive tests mainly evaluating visuospatial function and working memory. Lower uptake in NAWM at baseline was also associated with a growth in white matter lesion volume over time. Lower white matter uptake in amyloid PET is associated with cognitive decline and an increase in white matter lesion volume during the follow-up. Our study suggests that
Identifiants
pubmed: 31918239
pii: S2211-0348(20)30002-X
doi: 10.1016/j.msard.2020.101926
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101926Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.