Emerging roles of β-cell mitochondria in type-2-diabetes.
Free fatty acids
Mitochondria
Type-2-diabetes
β-Cell
Journal
Molecular aspects of medicine
ISSN: 1872-9452
Titre abrégé: Mol Aspects Med
Pays: England
ID NLM: 7603128
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
10
2019
revised:
23
12
2019
accepted:
27
12
2019
pubmed:
11
1
2020
medline:
9
2
2021
entrez:
11
1
2020
Statut:
ppublish
Résumé
Type-2-Diabetes (T2D) is the most common metabolic disease in the world today. It erupts as a result of peripheral insulin resistance combined with hyperinsulinemia followed by suppression of insulin secretion from pancreatic β-cells. Mitochondria play a central role in β-cells by sensing glucose and also by mediating the suppression of insulin secretion in T2D. Here, we will summarize the evidence accumulated for the roles of β-cells mitochondria in T2D. We will present an updated view on how mitochondria in β-cells have been associated with T2D, from the genetic, bioenergetic, redox and structural points of view. The emerging picture is that mitochondrial structure and dysfunction directly contribute to β-cell function and in the pathogenesis of T2D.
Identifiants
pubmed: 31918997
pii: S0098-2997(19)30122-0
doi: 10.1016/j.mam.2019.100843
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100843Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK099618
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest, financial or otherwise.